烯丙基钯催化区域选择性氧化制备甲基酮的研究  

Studies on Regioselective Oxidation of Zzabicycloalkanes by Means of Palladium Catalysts

作　　者：钟三保[1] 李仁利[1] 凌仰之[1] 刘维勤[1] 

机构地区：[1]北京医科大学药化教研室,四川省劳动卫生职业病防治研究所

出　　处：《合成化学》1995年第4期367-368,371,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家教委博士点基金资助项目

摘　　要：报道了以氯化钯作催化剂，区域选择性氧化９－烯丙基－１－氧代－４－氮杂双环［４．３．０］壬烷及１０－烯丙基－１－氧代－４－氮杂双环［５．３．０］癸烷，制备了９－丙酮基－１－氧代－４－氮杂双环［４．３．０］壬烷及１０－丙酮基－１－氧代－４－氮杂双环［５．３．０］癸烷。比较了不同催化条件和溶剂系统的反应收率，发现以ＰｄＣｌ＿２／对－苯醌为催化系统和以含水的ＤＭＦ溶剂系统氧化收率最高。Acetonyl-1-keto-4-azabicyclo[4.3.0] nonane and 10-acetonyl-1-keto-4-azabicyclo[5.3.0]decane were obtained by the palladium-catalyzed regioselective oxidation of their allyl compounds. Inthe comparison of the yields of this reaction with different catalyst system and solvent system,the best yield were obtained when the reaction was carried out using PdCl_2/ p- benzoquinone catalyst system in aqueousDMF.

关 键 词：烯丙基 氮杂双环烷烃 钯催化剂 甲基酮 

分 类 号：O626.322[理学—有机化学]