急性胰腺炎患者血小板与内皮细胞功能的研究  

Study on the function of platelet and endothelia cells in the patients with acute pancreatitis

作　　者：张连峰[1] 史成章[1] 张慧智 李继昌[1] 李锦堂[1] 

机构地区：[1]河南医科大学第一附属医院,郑州450052 [2]许昌市中心医院内科,许昌461000

出　　处：《河南医科大学学报》1995年第4期385-387,共3页Journal of Henan Medical University

摘　　要：采用ＥＬＩＳＡ法和单克隆酶联免疫吸附法测定了３９例急性胰腺炎患者和２４例正常人 的血浆内血小板α颗粒膜蛋白、血栓烷Ｂ２、６－酮－前列腺素Ｆ１ａ和血管性假血友病因子水平。结果显 示：急性胰腺炎患者血浆ＧＭＰ－１４０、ＴＸＢ２、ｖＷＦ：Ａｇ水平明显升高（Ｐ＜０．０１），６－酮－ＰＧＦ１ａ水平明 显降低（Ｐ＜０．０１）。动态观察发现：水肿型胰腺炎患者其血浆ＧＭＰ－１４０、ＴＸＢ３２、ＶＷＦ：Ａｇ水平于发 病第 ５ｄ出现下降趋势，而出血坏死型胰腺炎上述 ３项指标不仅没有下降趋势反而持续升高。提 示：胰腺炎患者血小板处于活化状态，内皮细胞功能受损，胰腺组织的血液循环障碍与血小板活化、 内皮细胞受损有密切关系。The levals of GMP-140,TXB2, 6-Keto-PGF1a and vWF:Ag in the plasma of 39 patients with acute pancreatitis were detected with enzym-linked immunosorbent assay(ELISA). The results showed that the levels of GMP-140, TXB2 vWP:Ag in the plasma of the patients with acute pancreatitis were significantly higher than those of the normal controls,and that the plasma level of 6-Keto-PGF1a in the ptients with acute pancreatitis was significantly lower than that of the normal control (P<0. 01). The levels of GMP-140, TXB2 and vWF: Ag in the plasma of patients with acute hamorrhagic necrotizing pancreatitis increased. These find- ings suggested that the disturbance of blood circulation in pancreatic tissue might be related fo the activation of platelet and become more serious with the increase of the number of activated platelets.

关 键 词：胰腺炎 血小板 内皮细胞 酶联免疫吸附 

分 类 号：R576.04[医药卫生—消化系统] R576.02[医药卫生—内科学]