膀胱内灌注噻替哌和尿激酶预防膀胱癌术后复发  

Intravesecal Instillation of thio-tepa and Urokinase in Prevention of recurrence of Bladder Carcinoma after Resection

作　　者：汪润炎 张天军[1] 

机构地区：[1]武汉市医学科学研究所,武汉市第一医院泌尿外科

出　　处：《湖北医科大学学报》1995年第2期143-144,共2页

摘　　要：膀胱内灌注噻哌和尿激酶预防膀胱癌术后复发是一种有效的方法。噻哌中加用尿激酶可以增加噻哌的抗癌效果。将噻哌的剂量减少到４０ｍｇ可以大大减少其对骨髓的抑制作用。噻哌价格低廉、易得，容易被病人所接受。Intravical instillation of thio-tepa and urokinase is an effective method for prevention of recurrence of bladder cancer after resection.urokinase increases the penetration of thio-tepa into tumor cells and stimulate the release of lysosomal hydrase.It destroys intracellular structure,and thus increases the anticancer effect.Decreases dose of thio-tepa and may reduce its marrow suppressive effect thio-tepa is prices low and easy to obtion is regarded as the first selected method for prevention of recurrence of bladder cancer after resection.

关 键 词：膀胱肿瘤 预防 复发 噻涕巴 尿激酶 药物疗法 

分 类 号：R737.140.5[医药卫生—肿瘤]