颌面骨纤维骨病变──272例临床病理研究  

Fibro-osseous Lesions of the Jaws:A Clinical Histopathologic Study of 272 Definitive Cases

作　　者：卢勇[1] 周志瑜[1] 何志秀[1] 雷荀灌[1] 张贤良[1] 

机构地区：[1]华西医科大学口腔医学院,华西医科大学病理学教研室

出　　处：《华西口腔医学杂志》1995年第1期32-35,共4页West China Journal of Stomatology

摘　　要：对２７２例颌面骨纤维骨病变（ＦＯＬ）进行了临床、病理研究，偏光镜观察和免疫组化染色，结果显示，国人最常见的ＦＯＬ为骨纤维异常增殖症４３．１％和骨化性纤维瘤３９．１％，牙骨质－分结构不良仅４例；显微镜下，病变由纤维性间质及其衍生的矿化物构成，矿化物形态一样，互相移行，有板层骨小粱、编织骨小梁、类圆形骨小体、均质片块及营养不良性钙化等，偏光镜也难以确切区分。骨形成蛋白（ＢＭＰ）主要位于部分间质和新形成的矿化物中，同病变的矿化物形成活性有关。ＦＯＬ的组织病在学形态交叉重叠多，强调临床、Ｘ线、病理三结合诊断。Abstract Two hundred and seventy-two cases of fibro-osseous lesions (FOL) of the jaws were reassessed. The most frequent FOL were fibrous dysplasia (43.1%) and ossifying fibroma (39.1%), while only four cases belonged to cemen-to-osseous dysplasia. Histologically FOL were composed of fibrous stroma and varying amounts of mineralized substance,which includes lamellar bone, woven bone, spheroidal calcifications, acellular conglomerations, and dystrophic calcifications.Immunohisto-chemistry stain for BMP demonstrated that the new-formed uncalcified matrix and the stroma near the mineralized substance were strong positive. All the FOL share common microscopic features which cause controversy in numeration, and definite diagnosis should base on the combined evaluation of clinical, radiological, and histopathological features.

关 键 词：颌面骨 纤维骨病变 组织病理学 临床分析 

分 类 号：R782.402[医药卫生—口腔医学]