分化型甲状腺癌^（131）Ⅰ治疗后甲状腺激素替代疗治方法学研究  

A Study on Methods of Thyroid Hormone Replacement after ￣(131)I Therapy of Differentiated Thyroid Carcinoma

作　　者：于南[1] 管昌田[1] 李进前[1] 田蓉[1] 

机构地区：[1]华西医科大学附一院核医学科

出　　处：《华西医学》1995年第3期323-325,共3页West China Medical Journal

摘　　要：分化型甲状腺癌１１Ⅰ治疗后均应进行甲状腺激素替代，旨在迅速纠正甲减并使血清ＴＳＨ降低到＜０．０３ｍｕ／Ｌ水平。本文在２５例病人中进行了两种替代治疗方法的对比研究。即常规剂量法，每日口服甲状腺片４０ｍｇｔｉｄ；饱和剂量法，甲状腺片逐日剂量按下列顺序给予，２４０ｍｇｔｉｄ、１２０ｍｇｔｉｄ、８０ｍｇｔｉｄ、４０ｍｇｔｉｄ……。结果显示：为使血清ＴＳＨ＜０．０３ｍＵ／Ｌ，对１３１Ⅰ治疗后已无残留甲状腺者，常规剂量需２５天，饱和剂量仅需７～１１天；对尚有残留甲状腺者，常规剂量亦仅需５天。表明对无甲状腺患者替代治疗宜采用饱和剂量法，而对有残留甲状腺者，仍以常规剂量为宜。A comparison of two methods of thyroid hormone replacement (routine dose, saturation dose) was performed in 25 patients after is 131I therapy of differentiated thyroid caminoma.In the group of routine dose, dry thyroid, 40mg tid was given, in the group of saturation dose, daily dry thyroid dose was given as follows: 240mg tid, 120mg tid,80mg tid,40mg tid…….The results suggested that for reducing serum TSH level to<0.03mU/L,in patients whose thyroid has been ablated, 25 days were needed from routine dose method, only 7～11 days weren edded from staturation dose method;in patients the thyroid still remained in place, only 5 days were needed from routine dose method. It is concluded that saturation dose method is suitakle for use in pationts whose thyroid has been ablated and routine dose method is suitable for use in patients the thyroid still remained.

关 键 词：甲状腺肿瘤 甲状腺激素 替代治疗 药物疗法 

分 类 号：R736.105[医药卫生—肿瘤]