（R）－2－硫代四氢噻唑－4－羧酸甲酯的合成及消旋化  

Synthesis of (R)-2-Thione-Thiazolidine-4-Carboxylic Methyl Ester and Its Racemization

作　　者：李叶芝[1] 李亚峰[1] 郎美东[1] 胡学山[1] 黄化民[1] 

机构地区：[1]吉林大学化学系

出　　处：《吉林大学自然科学学报》1995年第2期104-106,共3页Acta Scientiarum Naturalium Universitatis Jilinensis

基　　金：国家自然科学基金

摘　　要：Ｌ－半胱氨酸甲酯盐酸盐和二硫化碳在三乙胺存在下反应，当摩尔比为１：１．５：２时，得到的（Ｒ）－２－硫代四氢噻唑－４－羧酸甲酯，产率８０％；摩尔比为１：１．５１３．５时，得到Ｒ，Ｓ－２－硫代四氢噻唑－４－羧酸甲酯。另外，由（Ｒ）－２－硫代四氢噻唑－４－羧酸与甲醇及二氯亚硫酰反应，也得到（Ｒ）－２－硫代四氢噻唑－４－羧酸甲酯，产率为９８％，R)-2- thione- thiazolidine-4-carboxylic methyl ester((R)MCTT) was prepared from L-systeine Methyl ester hydrochloride reacting with carbon disulfide in the presence of triethylamine.When the molar ratio of L-systein methyl ester hydrochloride:carbon disulfide: triethylamine=1:1.5:2,(R)MCTT was produced in a 80%yield,when the molar ratio was 1:1.5:3.5,the specific rotation was reduced to When methyl alcohol and thionyl chloridereacted with(R)-2-thione-thiazolidine-4-carboxylic acid,(R)MCTT was obtained in a 98% yield,

关 键 词：硫代四氢噻唑 羧酸甲酯 消旋化 

分 类 号：O623.624[理学—有机化学]