多层螺旋CT灌注成像评价颌面部肿瘤微血管密度的研究  

Multi-slices spiral CT perfusion imaging evaluating of microvessel density in maxillofacial tumors

作　　者：李传亭[1] 吕玉波[1] 张东生[2] 张卫东[2] 吕京光[1] 柳澄[1] 武乐斌[1] 

机构地区：[1]山东省医学影像学研究所,济南250021 [2]山东省立医院口腔外科

出　　处：《中华放射学杂志》2005年第8期817-821,共5页Chinese Journal of Radiology

摘　　要：目的评价颌面部肿瘤多层螺旋CT(MSCT)灌注成像(PI)与微血管密度(MVD)的相关性。方法对31例颌面部肿瘤患者术前行MSCT灌注扫描,所得图像数据经计算机软件计算获得肿瘤感兴趣区(ROI)的时间密度曲线及灌注量(perfusion)、增强峰值(PEI)、达峰值时间(TTP)等灌注参数的数值。采用免疫组织化学方法测定病理标本的Ⅷ因子,检测病灶的MVD,分析MSCT灌注成像参数与MVD的相关性。结果颌面部肿瘤的微血管密度增高,且与肿瘤恶性程度明显相关。MSCT灌注参数中perfusion、TTP与MVD明显相关(P值均<0.05),而PEI则相关性不明显(P>0.05)。不同类型灌注曲线的MVD间差异有统计学意义(P<0.05),其中速升型组的MVD最高。结论MSCT灌注成像灌注参数perfusion、TTP及灌注曲线类型与肿瘤MVD明显相关,能反映肿瘤内微血管密度,有助于对颌面部肿瘤血管生成及其预后进行评价。Objective To evaluate the relationship between Multi-slices spiral （MSCT） perfusion and microvessel density （MVD） in maxillofacial tumors. Methods Thirty-one cases of maxillofacial tumors were studied with MSCT perfusion imaging before operation. The time-density curve, perfusion, time to peak（TIP） , and Peak enhancement imaging （PEI） of tumors were calculated. MVD of the tumors was measured with immuno-histochemical method by means of detecting factor Ⅷ in all the histologic specimens. Relativity analysis was carried between MSCT perfusion imaging parameters, perfusion curve types and MVD. Results MVD of maxillofacial tumors were higher than normal tissue. MVD remarkably correlated with malignancy of the tumors. Perfusion and time to peak （TIP） correlated well with MVD （t = 7.09,4. 10, P 〈 0. 05 ）, but peak enhancement imaging （PEI） did not（t =0. 76,P 〉0. 05）. Significant difference of MVD in three types of perfusion curve was found （ F = 8.09, P 〈 0. 05 ）. The tumors in the rapid ascend style had the highest MVD. Conclusion There are close correlations between MVD and perfusion, time to peak （TIP） and the shape of perfusion curve. MSCT perfusion imaging might evaluate MVD of maxillofacial tumors. It is a useful method in estimating the degree of angiogenesis and prognosis of maxillofacial tumors.

关 键 词：多层螺旋CT灌注成像 颌面部肿瘤 微血管密度 分子生物学 血管生成 

分 类 号：R739.8[医药卫生—肿瘤]