原发性中枢神经系统淋巴瘤15例临床分析  

Primary Central Nervous System Lymphoma (PCNSL): Report of 15 Cases

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作  者:何俊德[1] 陈葆[1] 杨韶丽[1] 

机构地区:[1]广州医学院第一附属医院神经外科,广东广州510120

出  处:《中国神经肿瘤杂志》2005年第2期135-137,共3页Chinese Journal of Neuro-Oncology

摘  要:背景与目的:原发性中枢神经系统淋巴瘤(Primarycentralnervoussystemlymphoma,PCNSL)是一种罕见的原发于脑和脊髓的非霍奇金淋巴瘤,近年其发病率有增高的趋势。本文通过对本院收治的15例原发性中枢神经系统淋巴瘤的病例分析,讨论和总结其临床特点及诊疗措施。方法:回顾性分析我院1990年至2004年收治的15例PCNSL的临床资料,均经手术后病理证实,术后均辅以放疗和/或化疗。结果:15例PCNSL,男性10例,女性5例,中位年龄43岁。就诊时的主要临床表现为颅内压增高、偏瘫和癫痫,肿瘤多位于幕上半球的额顶颞叶。11例行放疗及化疗,4例仅行化疗。中位随访14个月,8例死亡,6例死于复发。结论:原发性中枢神经系统淋巴瘤是一种恶性肿瘤,无特殊的临床表现和放射学征象。手术对明确诊断十分重要,应及早综合治疗,但治后复发及病死率高。BACKGROUND & OBJECTIVE: Primary central nervous system lymphoma is a rare type of non-Hodgkin's lymphoma (NHL), which originates in the central nervous system. Over the past decade, the incidence of PCNSL has increased. In this paper, we reported 15 cases of primary central nervous system lymphoma (PCNSL) and analyzed its clinical characteristics, diagnosis and treatment. METHODS: 15 cases of primary central nervous system lymphoma admitted from 1990 to 2004 were included in our study, all of which were confirmed after operation and received with radiotherapy and/or chemotherapy. RESULTS: There were 10 male and 5 female with median age of 43 year old. Symptoms included increase intracranial pressure, hemiparalysis and epilepsy. The most tumors located at the frontal and temperoparietal regions. Four cases underwent chemotherapy only, 11 cases underwent both radiotherapy and chemotherapy after operation. The median follow-up was 14 months, 8 patients died and 6 of them died of recurrence of the disease. CONCLUSION: PCNSL is a kind of malignant neoplasm, the clinic features and neuroimaging findings are nonspecific, surgery is very important for diagnosis. Main route of treatment is earlier diagnosis and postoperative radiotherapy and chemotherapy. However, survivals are limited and relapse are frequent in spite of treatment.

关 键 词:中枢神经系统 淋巴瘤 诊断 治疗 

分 类 号:R739.41[医药卫生—肿瘤]

 

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