钯催化偶合卟吩-并合杂环顺烯二炔二联体的合成  

Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction

作　　者：殷军港[1] 王进军[2] 沈荣基[3] 

机构地区：[1]兰州大学化学化工学院,兰州730000 [2]烟台大学应用化学系,烟台265005 [3]韩国仁济大学

出　　处：《高等学校化学学报》2005年第8期1474-1476,共3页Chemical Journal of Chinese Universities

基　　金：国家科技部中韩政府间合作研究(2002)项目;山东省技术创新重点项目(批准号:200391006008)资助.

摘　　要：The terminal alkyne was constructed in chlorin chromophore by Grignard reaction and oxidation to give chlorin 2 and 3, respectively. After deprotection the diketo chlorin 4 was obtained which was readily converted to the Zn-complex 5. Chlorin-enediyne dyads 6 fused with heterocyclic ring was synthesized by a palladium-catalyzed coupling reaction with 2-(1-hexynyl)-3-chlorothiophene.The terminal alkyne was constructed in chlorin chromophore by Grignard reaction and oxidation to give chlorin 2 and 3, respectively. After deprotection the diketo chlorin 4 was obtained which was readily converted to the Zn-complex 5. Chlorin-enediyne dyads 6 fused with heterocyclic ring was synthesized by a palladium-catalyzed coupling reaction with 2-（1-hexynyl）-3-chlorothiophene.

关 键 词：偶联反应 焦脱镁叶绿酸 卟吩-顺烯二炔二联体 光动力疗法 

分 类 号：O622[理学—有机化学]