大黄对胃癌手术患者急性炎性反应的调理作用  

Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer

作　　者：蔡骏[1] 宣正荣[1] 卫勇平[1] 杨海波[1] 王华[1] 

机构地区：[1]上海中医药大学龙华医院普外科,上海200032

出　　处：《中西医结合学报》2005年第3期195-198,共4页Journal of Chinese Integrative Medicine

基　　金：上海市卫生局科研基金资助项目(No.02 4008)

摘　　要：目的:观察胃癌患者围手术期使用中药大黄对急性炎性反应的调理作用。方法:采用前瞻性、随机、单盲、对照研究,将31例胃癌手术患者随机分为对照组(肠内营养组)14 例和研究组(大黄加肠内营养组)17例。研究组术前、术后第1、2天经鼻饲管给予中药大黄,两组患者手术后36 h开始给予等热量、等氮肠内营养支持6 d。术前1天,术后第1、3、7天分别检测血清C反应蛋白(C reactive protein, CRP)、白细胞介素6(interleukin 6, IL 6)、肿瘤坏死因子α(tumor necrosis factorα, TNF -α)等急性炎性反应指标及血清白蛋白、前白蛋白、转铁蛋白等营养指标。结果:两组患者术后均有急性炎性反应的发生及营养指标的下降,但研究组术后第3、7天的CRP、IL- 6、TNF -α水平较对照组有显著下降,术后排气、排便时间和肠鸣音的恢复显著提前。术后的营养指标两组患者间无明显差异。结论:胃癌患者围手术期应用大黄可以缓解急性炎性反应,促进术后胃肠道功能恢复,有利于实施术后肠内营养支持。Objective： To observe the effect of perioperative administration of rhubarb on the acute inflammatory response in patients with gastric cancer. Methods： In this prospective, single-blinded,controlled clinical trial, thirty-one patients with gastric cancer operatively treated were randomly divided into two groups, with 14 patients in control group and 17 in study group. Patients in both groups were given an isocaloric and isonitrogenous enteral diet. The enteral diet was started 36 hours after operation, and continued for 6 days. Patients in the study group were fed with rhubarb before operation, and at 1 day and 2 days after operation. Indexes of acute inflammatory response such as serum C-reactive protein （CRP）,interleukin-6 （IL-6） and tumor necrosis factor a （TNF-α）, and indexes of nutritional status such as serum albumin （ALB）, prealbumin （PA） and transferrin （TRF） were measured before operation, and at 1 day,3 and 7 days after operation. Results： Patients in both groups had acute inflammatory response, and theindexes of nutritional status decreased after operation. IL-6, CRP and TNF-α tested at 3 and 7 days after operation were lower in the study group as compared with those in the control group, and the recovery time of gastrointestinal motility such as borborygmus, gas elimination and defecation was shorter in the study group as compared with that in the control group. The indexes of nutritional status showed no significant differences between two groups after operation. Conclusion： Rhubarb can positively modulate the acute inflammatory response, promote the recovery of postoperative gastrointestinal motility, and benefit enteral nutrition support in patients who have undergone major operations for gastric cancer.

关 键 词：胃肿瘤 大黄 细胞因子 肠道营养 

分 类 号：R735.2[医药卫生—肿瘤] R283.661[医药卫生—临床医学]