恶性组织细胞增生症瘤细胞来源的探讨  

MALIGNANT HISTIOCYTOSIS:INVESTIGATION ON PHENOTYPE

作　　者：纪小龙[1] 李维华[1] 李红芬[1] 于占洋[1] 缪德标[1] 曾木英[1] 

机构地区：[1]解放军总医院

出　　处：《解放军医学杂志》1994年第2期112-114,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：恶性组织细胞增生症（简称恶组）一直被列入人体的组织细胞（单核吞噬细胞系统）来源的高度恶性肿瘤的范畴。自１９８５年以来，陆续有国外文献报道恶组的瘤细胞表达Ｔ淋巴细胞的标记，因而将恶组列入了Ｔ细胞淋巴瘤的范畴，但仍有一些文献并未同意这种新见解。结合瘤细胞的组织形态表现，我们发现，表达两种标记者常示瘤细胞分化较好吞噬现象明显；仅表达一种者，瘤细胞分化中等；两者均不表达者示瘤细胞分化差，几乎见不到吞噬现象。对此认识，仍有待进一步的深入探讨。Recent]y, some doubt has been cast on the actual histiocytic nature of the malignant cell inmalignant histioeytosis （MH）. Meanwhile, the demonstration of T cell gene rearrangement tn MH has been reported. 46 cases of MH were evaluated for clinical and histopathologic features and phenotype. The neoplastic cells involved predorninantly lymph modes, liver, spleen, hone marrow, lung, digestive tract, kidney etc,. In 21 cases of this group, 10 cases exhibited UCHLL1 ＋ and AACT＋, 3 cases UCHL1＋ and ACCT- , 3 eases UCHL1 and AACT ＋ and 5 eases UCHL1 and AACT-. The cells which showed positive markers of UCHIL： and AACT were well differentiates and the cells which showed negative markers of UCHL： and AACT were poorly differentiated histologically. This phenotypic results suggested that the primary stem cells of hemopoesis could he the origin ceil of MH.

关 键 词：恶性组织 细胞增生症 瘤细胞 组织细胞 免疫组化 

分 类 号：R730.1[医药卫生—肿瘤]