嘧啶亚硝脲小量多次给药治疗脑胶质细胞瘤实验研究  

Experimental study of frequent low-dose treatment with nimustine

作　　者：吴春明[1] 谢开友 刘荣耀[1] 孙丕通[1] 廉治刚[1] 李伟华[1] 

机构地区：[1]大连医科大学第一附属医院神经外科,辽宁大连116011 [2]旅顺口区人民医院神经外科,辽宁大连116021

出　　处：《中华神经外科疾病研究杂志》2005年第4期313-315,共3页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的探讨嘧啶亚硝脲(ACNU)小量多次给药治疗胶质瘤的效果。方法将C6胶质瘤细胞移植大鼠脑内,制作大鼠脑胶质瘤模型,术后第5d或第8d,将总量25mg/kg或40mg/kg的ACNU,分为1次或每周5次,腹腔内给药。结果术后第8d治疗开始,总量25mg/kg,对照组和小量多次给药组的生存期无明显差异,全量1次给药组生存期明显延长;总量40mg/kg,小量多次给药组比对照组的生存期明显延长(P<0.001)。术后第5d比第8d开始治疗,生存期进一步延长。结论大鼠脑胶质瘤模型,ACNU小量多次给药有效,但全量1次给药效果更显著。Objective To study the effect of frequent low-dose （FLD） treatment with nimuatine （ACNU） for rats with gliomas. Methods C6 glionra cells were intracerebrally inoculated and the ACNU treatment were began 5 or 8 days later （total dose of 25 or 40 mg/kg^-1 ）i. p. as either one bolus or smaller doses spread over 5 d per week.RcsultsBegitming at F,OStOperative 8 d with a total dose of 25mg/kg, survival duration did not differ between untreated controls and the FLD groups, while the bolus significantly prolonged survival. The FLD group showed some improvement heyond control survival at 40mg/kg （each P 〈0.001 ）, beginning treatment at F,OStOperative 5 d, rather than 8 d, prolonging survival somewhat further. Conclusion FLD treatment with ACNU is effective agaiust experimental glioma in rat, but it is less effective than bolus treatment.

关 键 词：大鼠 胶质瘤 小量多次给药 ACNU 化疗 

分 类 号：R739.41[医药卫生—肿瘤]