注意缺损多动障碍和儿茶酚-O-甲基转移酶基因无关联性(英文)  

No Association Between Attention-Deficit Hyperactivity Disorder and Catechol-O-Methyltransferase Gene in Chinese

作　　者：江三多[1] 吴晓东[1] 张野[1] 汤国梅[1] 钱伊萍[1] 汪栋祥[1] 

机构地区：[1]上海市精神卫生中心遗传室,上海200030

出　　处：《Acta Genetica Sinica》2005年第8期784-788,共5页

基　　金：国家自然科学基金项目资助(编号:39970774)~~

摘　　要：以往研究表明,儿茶酚胺系统可能参于注意缺损多动障碍(attentiondeficithyperactivityitydisorder,ADHD)的发生,而儿茶酚胺O甲基转移酶(catechelomethyltransferase,COMT)是一种降解多巴胺和去甲肾上腺素系统的儿茶酚胺神经递质的酶。因此,采用两种以家系为基础的分析方法,即传递不平衡实验(transmissiondisequilibriumtest,TDT)和单倍型为基础的单倍型相对风险率(haplotypebasedhaplotyperelativerisk,HHRR)去探讨COMT和中国人群中79个ADHD核心家系的关联性,ADHD诊断符合DSMIV的诊断标准。TDT(χ2=1.03,df=1,P>0.05)和HHRR(χ2=1.08,df=1,P>0.05)两种方法的分析结果表明,COMT等位基因不能优先传递给ADHD儿童,提示在中国人群中ADHD与COMT基因无关联性。Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder（ADHD）, Since catechel-o-methyltransferase（COMT） is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD, To test this hypothesis,we used two family-based analyses,the transmission disequilibrium test （TDT） and the haplotype-based haplotype relative risk （HHRR）, to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT （X^2 =1.03,df=1 ,P〉0. 05） and HHRR （X^2 =1.08,df= 1, P 〉 0.05） analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.

关 键 词：注意缺损多动障碍 儿茶酚-O-甲基转移酶 传递不平衡实验(TDT) 单倍型为基础的单倍型相对风险率(HHRR) 关联性 甲基转移酶 儿茶酚胺 酶基因 缺损 去甲肾上腺素 

分 类 号：R749.93[医药卫生—神经病学与精神病学]