肝脏放射性损伤早期效应SPECT与SPIO增强MRI影像分析  

SPECT and MR imaging analysis of early radiation-induced hepatic injury

作　　者：黄文才[1] 钧康 李勇[1] 周俊东[1] 杨仪[1] 刘增礼[1] 吴锦昌[1] 

机构地区：[1]苏州大学附属第二医院,苏州215004

出　　处：《核技术》2005年第8期625-629,共5页Nuclear Techniques

摘　　要：12只成年家兔40GyX线左半肝脏照射后第3—4d,进行99Tcm-Phy显像SPECT及SPIO增强MRI影像评价和病理分析。SPECT检查,本组有9只家兔肝脏照射区核素摄取减弱呈放射性稀疏区;阳性家兔24h延迟观察,肝脏照射区皆出现核素滞留现象。SPIO增强早期MRI,10只家兔肝脏照射区呈对比明显的高信号区;60min延迟扫描时,部分家兔两半肝脏强化对比减弱、分界线变模糊。照射后第4天的病理组织学检查发现肝脏照射区可见吞噬SPIO颗粒的Kupffer细胞数量下降。表明肝脏照射后早期Kupffer细胞吞噬和清除功能均有减退,上述两种影像学手段均能有效地检测出肝脏照射后早期网状内皮系统功能异常。With left liver irradiated by 40Gy single-dosed X-rays, 12 rabbits＇ liver SPECT with ^99mTc-Phy and SPIO-MR imaging were implemented in 3rd-4th day post-irradiation, and pathologic study was carried out at the same time. In our SPECT study, the radioisotope absorption of the irradiated livers decreased in 9 rabbits; and the positive rabbits demonstrated radioactive retention in 24-hour delayed observation. In early-phase SPIO enhanced MR imaging, the irradiated livers of 10 rabbits showed the positive appearance as high-signal region; however, the signal contrast of some rabbits＇ livers became weak in 60min delayed-enhanced MRI. In pathologic investigation of livers 4^th day post-irradiation, the number of Kupffer cells having swallowed SPIO in irradiated liver was less than that non-irradiated region. So we can conclude that both SPECT and MRI are effective in evaluating early effect of liver injury post-irradiations, i.e. dysfunction of reticuloendothelial system.

关 键 词：放射性肝损伤 单光子发射体层摄影 SPECT SPIO 磁共振成像 MRI 

分 类 号：R575[医药卫生—消化系统]