NF-κB、VEGF在胃不典型增生、胃癌中的表达及其意义  

The expressions of NF-κB and VEGF in gastric atypical hyperplasia and gastric carcinoma

作　　者：崔涛[1] 刘莹[1] 李凤朝[2] 

机构地区：[1]徐州医学院病理学教研室,江苏徐州221002 [2]徐州医学院附属医院病理科,江苏徐州221002

出　　处：《徐州医学院学报》2005年第4期286-288,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的探讨细胞核因子-κB(NF-κB)、血管内皮生长因子(VEGF)在胃不典型增生及胃癌中的表达、相互关系及在胃癌发生中的作用。方法采用免疫组化PowerVision两步法对84例胃癌和54例胃不典型增生组织中NF-κB、VEGF的表达进行检测,并对其与临床病理因素之间的关系进行分析。结果NF-κB、VEGF在84例胃癌组织中阳性表达率分别为59.52%、61.90%,在33例胃轻度不典型增生组织中阳性表达率分别为24.24%、33.33%,NF-κB、VEGF在胃癌与轻度不典型增生组之间存在统计学差异(P<0.05)。NF-κB表达与肿瘤的大小相关,VEGF表达与肿瘤大小、淋巴结转移、肿瘤浸润深度相关(P<0.05)。NF-κB与VEGF之间存在相关关系(P<0.05)。结论在胃癌中NF-κB可以通过上调VEGF的表达影响肿瘤血管的形成,进而促进肿瘤的生长、浸润、转移。Objective To explore the expression of NF-kB and vascular endothelial growth factor （VEGF） protein and their relationship in gastric cancer and atypical hyperplasia. Methods The expressions of NF - kB and VEGF were determined by Power Vision immunohistochemical analysis in 84 cases of gastric cancer and 54 gastric atypical hyperplasia. Results The positive rates of NF- kB（59.52% ）and VEGF （61.90%） were significantly higher in gastric cancer than in gastric atypical hyperplasia （ P 〈 0.05）. The overexpression of NF - kB in gastric cancer was related to tumor size （ P 〈 0.05）, and that of VEGF was related to lymph node metastasis, tumor size and the invasiveness of gastric cancer （ P 〈 0.05）. Positive correlation was found between the expressions of NF- kB and VEGF. Conclusion NF- kB plays an important role in the pathogenesis of gastric cancer by up- regulating the expression of VEGF.

关 键 词：细胞核因子-kB 血管内皮生长因子 胃癌 不典型增生 

分 类 号：R730.21[医药卫生—肿瘤] R735.2[医药卫生—临床医学]