阿伐麦布的合成  

Synthesis of Avasimibe

作　　者：蔡正艳[1] 宁奇[1] 周伟澄[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2005年第8期453-454,共2页Chinese Journal of Pharmaceuticals

摘　　要：1,3,5-三异丙基苯经氯甲基化、氰化和水解得到2,4,6-三异丙基苯乙酸,酰氯化后和氨基磺酸2,6-二异丙基苯酯缩合得到降血脂药阿伐麦布,总收率50%。Avasimibe was synthesized from 1,3,5-triisopropylbenzene via chloromethylation, cyanation and hydrolysis to give 2,4,6-triisopropylphenylacetic acid, followed by chlorization and then condensation with 2,6-diisopropylphenyl sulfamate, with an overall yield of 50% .

关 键 词：阿伐麦布 降血脂药物 合成 1 3 5-三异丙基苯 

分 类 号：R972.6[医药卫生—药品]