全肺照射联合PF方案对鼻咽癌肺转移的疗效分析  

Therapeutic efficacy of whole lung irradiation combined with PF regimen in the treatment of lung metastases from nasopharyngeal carcinoma

作　　者：胡建新[1] 刘长江[2] 陈海戈[1] 

机构地区：[1]广东省农垦中心医院放疗科,广东省湛江市524002 [2]广东医学院附属医院核医学科,广东省湛江市524001

出　　处：《实用医学杂志》2005年第16期1786-1787,共2页The Journal of Practical Medicine

摘　　要：目的:探讨全肺照射联合PF方案对鼻咽癌肺转移的疗效。方法:回顾分析81例鼻咽癌肺转移的随访资料,根据治疗方法不同分为小剂量全肺照射联合PF方案组和单纯化疗组,应用χ2检验分析肿瘤的缓解率和患者生存率。结果:放疗联合化疗组于病灶消失、缩小方面优于单纯化疗组,未控/进展情况少于单纯化疗组,两者差异有显著意义(P<0.05～0.01),而疗后病情稳定两组差异无显著性(P>0.05);放疗联合化疗组与单纯化疗组的12个月生存率差异无显著意义(P>0.05),而放疗联合化疗组18个月、24个月、≥36个月生存率明显高于单纯化疗组(P<0.05～0.01)。结论:小剂量全肺照射联合PF方案对鼻咽癌肺转移的治疗是目前较为理想的治疗方案。Objective To explore the therapeutic efficacy of whole lung irradiation combined with PF regimen in the treatment of lung metastases from nasopharyngeal carcinoma (NPC). Methods Follow-up data of 81 cases with lung metastases from NPC were analyzed retrospectively. The patients were divided into two groups. Group A received low dose whole-lung irradiation combined with PF regimen. Group B receive PF regimen chemotherapy only. χ 2 test was used to the remission and survival rate of group A and group B were compared with statistical analysis. Results The CR and PR of group A were significant higher than that of group B(P< 0.05), and the PD rate of group A was lower than that of group B(P< 0.05). The NC rates between group A and group B had no statistical significance(P >0.05). Twelve- month survival rates between group A and group B had no statistical significance(P >0.05), while the 18, 24 and longer than 36 months survival rate of group A was significant higher than that of group B(P < 0.05). Conclusion Low dose whole-lung irradiation combined with PF regimen is currently an effective treatment modality for the treatment of lung metastases from NPC.

关 键 词：全肺照射 PF方案 鼻咽癌 肿瘤转移 疗效分析 

分 类 号：R739.63[医药卫生—肿瘤]