血清tPSA、fPSA/tPSA及PSAD在前列腺良恶性疾病鉴别诊断中的价值  

Value of differential diagnosis of serum tPSA, fPSA/tPSA and PSAD in benign andmalignant prostatic diseases

作　　者：任伟[1] 徐祗顺[2] 张东青[2] 

机构地区：[1]山东大学医学院 [2]山东大学齐鲁医院,山东济南250012

出　　处：《山东医药》2005年第21期1-2,共2页Shandong Medical Journal

摘　　要：目的探讨血清总前列腺特异抗原(tPSA)、游离PSA(fPSA)与tPSA的比值(F/T)、前列腺特异抗原密度(PSAD)在前列腺增生(BPH)和前列腺癌(PCa)鉴别诊断中的价值。方法检测65例BPH患者及38例PCa患者的血清tPSA、fPSA,经腹部B超测定前列腺的前后径、左右径、上下径,并计算出F/T、前列腺体积(PV)及PSAD,进行比较。结果在灰区外高值区,tPSA、PSAD在两组间差异有显著性(P均<0.01),F/T差异无显著性(P>0.05);在灰区,两组间tPSA差异无显著性(P>0.05),而F/T、PSAD差异有显著性(P均<0.01);在灰区外低值区,tPSA、F/T及PSAD在两组间差异无显著性(P>0.05)。结论以F/T及PSAD作为tPSA的辅助指标,对PSA灰区PCa的诊断具有明显临床意义。Objective： To study the value of serum total prostate specific antigen （tPSA）, the ratio of free prostate specific antigen （fPSA） and tPSA （F/T）,prostate specific antigen density（PSAD） in the differential diagnosis of benign and malignant prostatic diseases. Methods： The tPSA, fPSA and prostatic volume were analysed in 38 prostate cancer and 65 BPH patients. The F/T ratio and PSAD were obtained. The tPSA,F/T ratio and PSAD in patients both within and outside the gray zone were analysed. Results： tPSA and PSAD were significantly different between patients with prostate cancer and BPH （P＜0. 01 both） when the assessed level were much higher beyond gray zone. When the assessed level were within the gray zone ,the F/T and PSAD were different between the two condition （P＜0.01）. However, tPSA, F/T and PSAD had no significant differences between the two conditions （P＞0.05） in the lower value range beyond the gray zone. Conclusion.. The F/T ratio and PSAD are adjuvant markers to tPSA,and have clinical significance in differential diagnosis on patients whose tPSA in diagnostic gray zone.

关 键 词：前列腺癌 前列腺增生 前列腺特异抗原 前列腺特异抗原密度 

分 类 号：R737.25[医药卫生—肿瘤]