肺癌患者单核细胞趋化蛋白-1含量及其活性的研究  

Expression of monocyte chemoattract protein-1 and its activity in lung cancer

作　　者：龙发[1] 王达安[2] 李菁[2] 颜亮[2] 屈洋[2] 王云[1] 全采娟[3] 彭勃[3] 罗文熙[3] 张永昶[1] 

机构地区：[1]深圳市罗湖人民医院呼吸内科,广东深圳518001 [2]暨南大学医学院病理生理学教研室,广东广州510632 [3]广东医学院呼吸研究所,广东湛江524001

出　　处：《中国病理生理杂志》2005年第8期1569-1571,共3页Chinese Journal of Pathophysiology

基　　金：广东省卫生厅科研基金资助项目(No.960202)

摘　　要：目的:探讨单核细胞趋化蛋白-1(MCP-1)含量及其活性-单核细胞趋化活性(MCA)变化与肺癌发病的关系。方法:以ELISA法测定肺癌组、良性肺病组及健康对照组支气管肺泡灌洗液(BALF)中MCP-1的含量,并同时测定各组BALF的MCA。结果:肺癌组BALF的MCP-1含量及MCA明显高于良性肺病组及健康对照组,均P<0·01。但肺癌组BALF中MCP-1含量与MCA的相关系数却明显低于良性肺病组和健康对照组;即在肺癌组MCA活性并没有随MCP-1含量增加而成正比地增加。结论:肺癌患者可能存在单核细胞趋化活性不足。AIM： To investigate the relationship among MCP- 1 and monocyte chemoattract protein activity （MCA） and pathogenesis of lung cancer. METHODS： 173 patients were involved in the study and divided into three groups： group A：lung cancer group （60 patients） ; group B： benign lung disease group （55 patients） and group C- healthy control group （58 patients）. MCP - 1 level and MCA in bronchoalveolar lavage fluid （BALF） were measured. RESULTS： The concentration of MCP-1 and MCA in BALF in group A were much higher than those in group B and group C （ P 〈 0.01 ）, but the increase in MCA were not in direct proportion to the increase in MCP- 1 in the patients with lung cancer. CONCLUSION： Monocyte chemoattract activity of the patients with lung cancer may be insufficient.

关 键 词：肺肿瘤 支气管肺泡灌洗液 单核细胞化学吸引蛋白质1 

分 类 号：R363[医药卫生—病理学]