细胞对缺氧的感受和信号转导  

Cellular oxygen sensors and signal transduction

作　　者：王迪浔[1] 邓世苇[1] 

机构地区：[1]华中科技大学同济医学院,湖北武汉430030

出　　处：《中国病理生理杂志》2005年第8期1604-1606,1618,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(39730190)

摘　　要：Hypoxia is a commenest pathological process. The cellular oxygen sensors and signal transduction involved in hypoxic responses are so far not fully elucidated. There are many theories. Perhaps the oxygen sensors are different among different kinds of cells, and between acute and chronic hypoxic responses. The mitochondria cytochrom-oxidase-H2O2 might be the principal pathway leading to the constrictive response of pulmonary smooth muscle cells to hypoxia. The heme protein - reactive oxygen pathway might mediate the response of glomus cells in carotid body to hypoxia. The NADPH oxidase might be the oxygen sensor in airway chemoreceptor. As for chronic hypoxic responses, the oxygen dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation has been paid great attention in recent years.Hypoxia is a commenest pathological process. The cellular oxygen sensors and signal transduction involved in hypoxic responses are so far not fully elucidated. There are many theories. Perhaps the oxygen sensors are different among different kinds of cells, and between acute and chronic hypoxic responses. The mitochondria cytochrom - oxidase - H2O2 might be the principal pathway leading to the constrictive response of pulmonary, smooth muscle cells to hypoxia. The heme protein - reactive oxygen pathway might mediate the response of glomus cells in carotid body to hypoxia. The NADPH oxidase might be the oxygen sensor in airway chemoreceptor. As for chronic hypoxic responses, the oxygen dependent regulation of hypoxia - inducible factors by prolyl and asparaginyl hydroxylation has been paid great attention in recent years.

关 键 词：细胞 缺氧 感受器 信号转导 

分 类 号：R363[医药卫生—病理学]