细胞内炎症信号通路交汇作用研究进展  

Advances in cross-talk of cellular signalling pathways associated with inflammatory response

作　　者：刘辉[1] 姚咏明[1] 

机构地区：[1]中国人民解放军第304医院全军烧伤研究所基础部,北京100037

出　　处：《中国病理生理杂志》2005年第8期1607-1613,1627,共8页Chinese Journal of Pathophysiology

基　　金：国家重点基础研究发展规划项目(No.G1999054203);国家杰出青年科学基金资助项目(No.30125020);全军杰出中青年人才专项基金资助项目(No.98J013)

摘　　要：Janus kinase-signal transduction and transcription activator (JAK-STAT), mitogen- activated protein kinase (MAPK) and nuclear factor κB (NF-κB) are three important cellular signalling pathways, which play pivotal roles in regulation of cellular physiologic as well as pathophysiologic functions. Based on the elucidation of the research progress of three signalling cascades, respectively, the current review focuses on the cross-talk of these signalling transduction, and the up-to-date details are also presented on their regulation in inflammatory response.Janus kinase- signal transduction and transcription activator （JAK - SLAT）, mitogen - activated protein kinase （MAPK） and nuclear factor κB （NF- κB） are three important cellular signalling pathways, which play pivotal roles in regulation of cellular physiologic as well as pathophysiologic functions. Based on the elucidation of the research progress of three signalling cascades, respectively, the current review focuses on the cross - talk of these signalling transduction, and the up - to - date details are also presented on their regulation in inflammatory response.

关 键 词：信号转导 炎症 有丝分裂素激活蛋白激酶类 NF-ΚB 

分 类 号：R363[医药卫生—病理学]