肺癌三维适形放疗中急性放射性食管炎的相关因素分析  

Factors predicting acute radiation esophagitis in the treatment of three-dimensional conformal radiotherapy for lung cancer

作　　者：王颖杰[1] 王绿化 

机构地区：[1]蚌埠医学院附属医院放射治疗科,安徽蚌埠233004 [2]中国医学科学院中国协合医科大学肿瘤研究所肿瘤医院放射治疗科,北京100021

出　　处：《淮海医药》2005年第4期259-261,共3页Journal of Huaihai Medicine

摘　　要：目的分析肺癌三维适形放射治疗中急性放射性食管损伤的发生率及其相关因素。方法1999年3月～2003年9月首程行三维适形放疗的肺癌病例,总计112例,男87例,女25例。中位年龄64岁(20～87岁)。其中,非小细胞肺癌97例,小细胞肺癌15例。放疗中位单次剂量2Gy,每周5次,中位总剂量60Gy。结果2级急性放射性食管损伤8.9%(10/112)。单因素分析显示,疗前体重下降≥5%和行化疗或同时化放疗的病例,急性放射性食管损伤的发生率升高,统计学均有显著差异,其中,疗前体重下降≥5%在多因素分析也有统计学差异(P=0.016)。结论急性放射性食管损伤相关的因素是疗前体重下降≥5%。Objective To report the incidence of acute radiation esophagitis and analyze the factors as predictors of acute radiation esophagitis in the treatment of three-dimensional conformal radiotherapy （3DCRT）for lung cancer. Methods Between March 1999 and September 2003,112 lung cancer patients treated with 3DCRT were reviewed. This population consisted of 87 men and 25 women,including 97 cases with non-small cell lung cancer and 15 with small cell lung cancer. The median age was 64 years. Radiotherapy was delivered at 2Gy fraction, 5 fractions per week. The total dose was 60Gy. Results Acute radiation esophagitis was observed in 8. 9% patients with grade 2. Univariate analysis revealed that many parameters （Pre-treatment weight loss more than 5% ,chemotherapy,concurrent chemotherapy）were significantly associated with acute radiation esophagitis. Multivariate analysis revealed that pre-treatment weight loss more than 5% was the most important risk factor for acute radiation esophagitis （P=0. 016）. Conclusions Pre-treatment weight loss more than 5% is the most important risk factor for acute radiation esophagitis in this study.

关 键 词：肺肿瘤/放射疗法 放射疗法 适形 放射性食管损伤 

分 类 号：R734.2[医药卫生—肿瘤]