三氧化二砷联合木黄酮对人胃癌细胞株SGC-7901的作用  

The Interaction between Arsenic trioxide and Genistein on human gastric car cinoma cell line SGC-7901

作　　者：宋林[1] 张俊文[1] 

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016

出　　处：《现代医药卫生》2005年第16期2095-2097,共3页Journal of Modern Medicine & Health

摘　　要：目的:体外观察三氧化二砷及木黄酮对人胃癌细胞株(SGC-7901)的相互作用。方法:采用MTT法检测药物效应,利用中效原理判定两药合用的效果。结果:两种药单独应用时随着药物剂量增加,其效应也增加,呈剂量-效应关系;两药合用时合用指数均小于1(CI<1)。结论:三氧化二砷联合木黄酮对人胃癌细胞株SGC-7901的作用是协同作用。Objective：To observe the effects of Arsenic trioxide and C, enistein on human gastric carcinoma cell line SGC - 7901 .Methods：The MTr assay and median - effect principle were used.Results： The effects of the inividual drugs were enhanced as drug concentration increased.The interaction of the two drugs was synergistic at all ceneentrations （CI 〈 1） . Conclusion： The interaction of the Arsenic trioxide and C, enistein were synergistic on human gastric carcinoma cell line SGC - 7901.

关 键 词：三氧化二砷 木黄酮 联合应用 中效原理 合用指数 抗癌药物敏感性试验 

分 类 号：R73[医药卫生—肿瘤]