脑缺血预处理对离体大鼠心脏再灌注损伤的影响  

Protective effect of brain ischemia preconditioning on myocardium from ischemia-reperfusion injury.

作　　者：余立群[1] 金芃芃[1] 杨毅[2] 张玉青[1] 夏钦贵[1] 

机构地区：[1]温州医学院生理学教研室,浙江温州325035 [2]温州医学院诊断学教研室,浙江温州325035

出　　处：《温州医学院学报》2005年第4期271-273,共3页Journal of Wenzhou Medical College

摘　　要：目的:研究脑缺血预处理对离体大鼠心脏再灌注损伤有无保护作用。方法:采用离体大鼠缺血再灌注模型,22只雄性SD大鼠随机分成单纯缺血复灌组(IR),经典预处理组(IPC),脑缺血预处理组(BPC),在Langendorff装置上对大鼠离体心脏进行灌流。比较分析各组左室舒张末期压力(LVEDP),左室发展压(LVDF)和心肌梗死面积。结果与I/R组比较,脑缺血预处理能明显增加复灌各个时间点的LVDP 恢复率,抑制LVEDP的增加(P<0.01),明显减小心肌梗死范围;且与经典预处理组比较差异无显著性。结论:脑缺血预处理对离体大鼠的心脏有保护作用,其保护程度与经典预处理的保护作用相似。Objective： To investigate the protective effect of brain ischemia preconditioning on isolated rat heart of ischemia-reperfusion injury, Methods： Langendorff reperfusion models of cardiac ischemic-reperfusion was established. Twenty-two male SD rats were randomly divided into three groups： ischemic/reperfusion （I/R） group, classic ischemia preconditioning （IPC） group and brain ischemia preconditioning （BPC） group. Left ventricular end-diastolic pressure （LVEDP）, the recovery of left ventricular developed pressure （LVDP%）, and myocardial infarct size were analyses. Results： In BPC group, LVDP% was significantly improved, and LVEDP decreased, infarct size reduced, compared with the I/R group, Conclusion： Brain ischemia preconditioning has a protective effect on myocardium from ischemia-reperfusion in.Jury. The protective effectiveness is similar to that of heart ischemic preconditioning.

关 键 词：大鼠脑缺血预处理缺血再灌注心肌保护 

分 类 号：R363.2[医药卫生—病理学]