热化疗对颌面部鳞癌细胞热休克蛋白70表达的影响  

Influence of the Expression of Heat Shock Protein 70 in Maxillofacial Squamous Cell Carcinoma by Themochemotherapy

作　　者：王升志[1] 王锂 高向东[1] 成洲[1] 毕洪广[1] 王大章[3] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院口腔颌面外科,山东烟台264000 [2]山东烟台第一中学医务所口腔科,山东烟台264001 [3]四川大学华西口腔医学院口腔颌面外科教研室,四川成都610041

出　　处：《华西口腔医学杂志》2005年第4期277-279,共3页West China Journal of Stomatology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(03BS038);广东省医学科研课题基金资助项目(A2002434)

摘　　要：目的探讨热化疗对颌面部鳞癌细胞热休克蛋白(HSP)70表达的影响。方法12例鳞癌患者给予每周2次,5周10次为1个疗程的热化疗处理。12例患者均静脉注射平阳霉素8mg,43℃微波热疗40min。于患者治疗前及治疗5次后取肿瘤组织制作标本。用SP免疫组织化学法观察肿瘤细胞HSP70的表达。结果热化疗1疗程结束后12例患者肉眼未见明显包块,免疫组织化学染色提示治疗中癌细胞HSP70表达增多。结论热化疗可以明显提高HSP70在肿瘤细胞中的表达,HSP70通过其抗原递呈等系列免疫效应,发挥抗肿瘤作用。Objective To study the influence of themochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma.Methods 12 patients were treated with themochemotheraphy twice a week, altogether 10 times. After 8mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43℃ for 40 min. The part of carcinoma tissue was removed with surgical operations at before treatmem and afire five times of treatment. The expression of HSP70 in tumor cells was determined by SP immunohitochemcial method. Results The expression of HSP70 in tumor cells was enhanced obviously by thermochemothempy. Conclusion Special high expression of HSP70 in the tumor cells was induced by thermochemotherapy.With the antigen presenting action and other action,HSP70 have special antitumor effect.

关 键 词：热化疗 热休克蛋白 肿瘤 

分 类 号：R739.8[医药卫生—肿瘤]