PTEN在非小细胞肺癌中的表达及其意义  

THE EXPRESSION AND ITS SIGNIFICANCE OF PTEN PROTEIN IN NON-SMALL-CELL LUNG CANCER

作　　者：刘伟[1] 于文成[2] 时衍同[1] 熊玲[1] 秦筱梅[2] 

机构地区：[1]日照市人民医院呼吸内科,山东日照276826 [2]青岛大学医学院附属医院呼吸内科

出　　处：《齐鲁医学杂志》2005年第3期217-218,221,共3页Medical Journal of Qilu

摘　　要：①目的探讨肿瘤抑制基因PTEN蛋白的表达与非小细胞肺癌临床病理因素的关系。②方法采用SABC免疫组化法检测43例非小细胞肺癌及20例癌旁正常肺组织石蜡包埋标本PTEN蛋白的表达。③结果肺癌PTEN蛋白阳性表达率为46.5%,癌旁肺组织为95.0%,两组间比较差异有显著性(χ2=13.61,P<0.01)。PTEN蛋白的表达与肺癌组织的细胞分化程度、淋巴结转移状态以及病人的预后密切相关(χ2=5.31～8.50,P<0.05、0.01),而与肺癌病人的年龄、性别、肿瘤大小、组织类型及临床分期等均无关(χ2=1.08～2.73,P>0.05)。④结论PTEN蛋白的异常表达可能在肺癌的发生、发展和淋巴结转移过程中起重要作用。Objective To study the relationship between the expression of PTEN and clinicopathological features in patients with non-small-cell lung cancer（NSCLC）. Methods Immunohistochemistry stain（SABC） method was applied to investigate the expression of PTEN protein in specimens of 43 NSCLC and 20 normal lung tissue adjacent to lung carcinoma. Results The positive rate of PTEN was significantly lower in patients with NSCLC（46.5%） than that in normal lung tissue adjacent to carcinoma（95.0 %） （x^2=13.61, P〈0.01 ）. The expression of PTEN was closely correlated with cellular differentiation, lymph node metastasis and prognosis in patients with NSCLC（x^2=5.31-8.50;P〈0.05, 0.01）, but not with age, sex, tumor size, TNM stage, or histological type of lung cancer（x^2=1.08-2.73, P〉0.05）. Conclusion Abnormal expression of PTEN protein may play an important role in the occurrence, development and lymph node metastasis of lung cancer.

关 键 词：肺肿瘤 蛋白质PTEN 病理学 临床 

分 类 号：R734.2[医药卫生—肿瘤]