四环素类似物的体外抗菌活性初探  

Antibacterial activity of tetracycline analogues in vitro

作　　者：杨摙 黄文才[1] 翁玲玲[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第4期326-327,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:130070883)

摘　　要：目的检测四环素类似物的体外抗菌活性,以观察类似物的抗菌和趋骨活性的相关性。方法采用纸片琼脂扩散法及试管二倍稀释法。结果四环素类似物的抗菌活性较四环素大幅降低或完全消失。结论通过对四环素的结构简化,保留其趋骨活性而使抗菌作用减弱或消失。OBJECTIVE To study antibacterial activity in vitro and bone - affinity of tetracycline analogues to observe their correlation. METHODS Inhibitory zone diameter was measured by disc agar diffusion（DAD）.The minimal inhibitory concentration （MIC）was scaled by tube dilution method. RESULTS Comparing with tetracyline, antibacterial activity in vitro of the analogues was significantly attenuated or elimiuated. CONCLUSION It is possible that tetracycline analogues could retain bone- affinity while attenuate or eliminate antibacterial activity in vitro by simplification of their structure.

关 键 词：四环素 类似物 体外抗菌活性 趋骨性 

分 类 号：R914.5[医药卫生—药物化学]