Calmodulin regulates the post-anaphase reposition of centrioles during cytokinesis  

作　　者：Yue Yue YU Gu DAI Fei Yan PAN Jie CHEN Chao-Jun LI 

机构地区：[1]Jiangsu Key Laboratory for Molecular ＆ Medical Biotechnology, School of Life Sciences, Nanjing Normal University. Nanjing 210097, China

出　　处：《Cell Research》2005年第7期548-552,共5页细胞研究（英文版）

基　　金：This work was supported by National Natural Science Foundation of China(Grant No.30170453);Founda tion of Ministry of Education of China for Distinguished Young Teachers(Grant No.[2001]39)awarded to Chao-Jun LI.

摘　　要：A transient postanaphase repositioning of the centriole is found to control the completion of cytokinesis. Using agreen fluorescent protein-calmodulin fusion protein as a living cell probe, we have previously found that calmodulin isassociated with the initiation and progression of cytokinesis. In this study, we further studied the effect of calmodulinon the repositioning of the centriole and subsequent cell cycle progression. When activity of calmodulin is inhibited, theregression of the centriole from the intercellular bridge to the cell center is blocked, and thus the completion of celldivision is repressed and two daughter cells are linked by longer cell bridge in perturbed cells. W7 treatment duringcytokinesis also results in unfinished cytokinesis and stopped G1 phase. These results suggest that calmodulin activity isrequired for centriole repositioning and can affect the completion of cytokinesis and cell cycle progression.

关 键 词：CaM centriole reposition CYTOKINESIS W7. 

分 类 号：Q253[生物学—细胞生物学]