十二指肠溃疡的不同疗法对照研究  

A Comparative Study of Different Drugs in the Treatment of Duodenal Ulcer

作　　者：李尚勤[1] 徐克成[2] 左建生[2] 孟宪镛[2] 

机构地区：[1]北京邮电医院 [2]南通医学院蛇口联合医院消化病中心,518067

出　　处：《江苏医药》1995年第7期440-442,共3页Jiangsu Medical Journal

摘　　要：88例活动期十二指肠溃汤（DU）患者，随机分配到雷尼替丁（n＝27），洛赛克（n＝31）和由羟氨苄青霉素、四环素、灭滴灵组成的三联抗菌疗法组（n＝30）治疗。4周愈合率无明显差异。1年内复发率分别为80％、55％、30％。在尿素酶试验转阴、幽门螺杆菌（HP）清除、胃窦和十二指肠球部炎症减轻及肠粘膜超微结构的改变上，以抗菌疗法组为最优，洛赛克组次之，雷尼替丁组无明显改变。Eighty-eight patients with active duodenal ulcer were randomly allocated to one of three kinds of treatment: ranitidine group (n = 27),omeprazole group (n= 31 ) and combined antibiotic group composed of amoxycillin,tetracycline and Metronidazole (n= 30). Ulcer healing rates after 4-weeks treatment did not show marked difference. Relapse rates of duodenal ulcer in one year were 80%,55%,30% respectively. Urease test turned to be negative, Helicobacter Pylori being cleaned off, subsidence of innammation in antrum and duodenum and recovery of superstructure around the ulcer were achieved bestly in the antibiotic group, omeprazole group was the second and ranitidine group had no marked improvement. This study shows:The an tibacterial therapy can achive the best healing quality of DU owing to the cleance of Helicobacter Pylori, absence of which may be the cause of low relapse rate of the ulcer. Omeprasole achieved the better healing quality than ranitidine because it was able to inhibit the HP activity.

关 键 词：十二指肠溃疡 药物疗法 对照研究 

分 类 号：R573.1[医药卫生—消化系统]