DNA损伤修复基因hOGG1的遗传多态与肝癌易感性研究  

Studies on Association between Susceptibility of Hepatocellular Carcinoma and Genetic Polymorphism Ser326Cys of DNA Repair Gene hOGG1

作　　者：张昊[1] 郝冰涛[2] 贺福初[2] 

机构地区：[1]河南省人民医院老年病研究中心,郑州市450003 [2]军事医学科学院

出　　处：《中国肿瘤临床》2005年第15期841-843,共3页Chinese Journal of Clinical Oncology

基　　金：国家"863"高技术发展项目基金资助(编号:2001AA224011)

摘　　要：目的:探索DNA损伤修复基因hOGG1的遗传多态Ser326Cys与肝细胞肝癌易感性的关系。方法:对96例原发性肝细胞肝癌患者和96例对照外周血DNA进行测序分型。结果:Ser/Cys杂合子个体的OR值为1.5,Cys/Cys纯合子个体的OR值为1.9,表现出剂量效应。结论:DNA修复基因hOGG1的Cys等位基因可能增加肝细胞肝癌的遗传易感性。Objective： To explore the association between the susceptibility of hepatocellular carcinoma （HCC） and the genetic polymorphism Ser326Cys of DNA repair gene hOGG1. Metholds： Ninety six patients with HCC and ninety six subjects of control group in DNA damage repair gene hOGG1 Ser326Cys polymorphism were genotyped. Results： It was found that the OR of heterozygote Ser/Cys subjects was 1.5 and that of homozygosity Cys/Cys was 1.9. Conclusion： Allele Cys for hOGG1 gene may increase the genetic susceptibility of HCC.

关 键 词：原发性肝细胞肝癌 DNA修复基因 遗传多态 

分 类 号：R735.7[医药卫生—肿瘤]