沙培林联合顺铂治疗恶性腹腔积液的疗效观察  

Combined group A streptococcus preparation (sapylin) and cisplatin for malignant peritoneal effusion

作　　者：潘静[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院综合科,北京100021

出　　处：《中华肿瘤杂志》2005年第7期442-444,共3页Chinese Journal of Oncology

摘　　要：目的评价沙培林联合顺铂(DDP)治疗恶性腹腔积液的临床效果。方法60例伴有大量腹腔积液的晚期癌症患者,随机分为两组,每组30例。沙培林+DDP组经导管腹腔内注入沙培林和DDP治疗,DDP组仅用DDP治疗。结果沙培林+DDP组完全缓解11例,部分缓解16例,有效率为90.0%,高于DDP组(63.3%)。沙培林+DDP组临床受益率为40.0%,高于DDP组(26.7%)。不良反应主要为发热、恶心、呕吐,患者可耐受。结论沙培林联合DDP治疗恶性腹腔积液疗效明显,不良反应轻,具有一定的临床应用价值。Objective To evaluate the effect of Group A streptococcus preparation （sapylin） combined with cisplatin on the malignant peritoneal effusion in patients with advanced cancer. Methods Sixty advanced cancer patients with large amount of peritoneal effusion were divided into two groups： sapylin ＋ cisplatin（DDP） group （30 patients） and control group （ DDP alone, 30 cases）. All the chemotherapeutic agents were injected intraperitoneally through a catheter. Results In sapylin ＋ cisplatin（DDP） group, 11（36.7%） patients showed CR and 16 （53.3%） PR. The overall response rate （CR＋ PR） was 90.0%. Those of DDP alone group were 16.7% and 46.7%, the overall response rate was 63.3%. The main adverse effects were fever, nausea, and vomiting. Conclusion Combined Group A streptococcus preparation （sapylin） and cisplatin is more effective than cisplatin alone for the malignant peritoneal effusion in patients with advanced cancer, and the adverse effects are tolerable.

关 键 词：沙培林 顺铂 治疗 恶性腹腔积液 疗效观察 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]