氟西汀治疗40例癌症相关性抑郁症的效果  

Efficacy of Fluoxetine in the Treatment of Depression Associated with Cancer

作　　者：吴树强[1] 贾勇士[1] 吕世良[1] 张丽萍[1] 许丽萍[1] 

机构地区：[1]浙江省人民医院,浙江杭州310014

出　　处：《肿瘤学杂志》2005年第4期294-295,共2页Journal of Chinese Oncology

摘　　要：[目的]观察氟西汀治疗癌症相关性抑郁症的疗效。[方法]40例癌症合并抑郁症患者抗肿瘤治疗的同时给予氟西汀治疗,观察抗肿瘤治疗结果与抑郁症治疗效果的关系及停用氟西汀后的复燃率。[结果]33例抑郁缓解,缓解率82.5%。经抗肿瘤治疗有效的25例,口服氟西汀后抑郁症状缓解23例,抑郁缓解率为92.0%,停药后抑郁复燃2例,复燃率仅为8.7%;经抗肿瘤治疗无效15例,其抑郁缓解10例,缓解率66.7%,停药后复燃8例,复燃率高达80.0%。[结论]氟西汀可明显缓解癌症患者的抑郁症状,对经抗肿瘤治疗有效且无明显躯体症状的癌症患者,经氟西汀治疗抑郁缓解后可停抗抑郁药治疗,而对抗肿瘤治疗无效的癌症患者,建议长期应用抗抑郁药。[Purpose] To study the efficacy of fluoxetine on depression associated with cancer. [Methods] Forty cancer patients combined with depression were managed with anti-cancer treatment and fluoxetine.The correlation of anti-cancer treatment and therapeutic effect of depression, and the recurrence rate of depression after withdrawal of fluoxetine were studied. [Results] Among 25 patients who had response to anticancer therapy, 23 patients showed depressive symptoms ameliorated after withdrawal of fluoxetine, and the remission rate of depression was 92.0%. There were 2 recrudescence of depression after withdrawal of fluoxetine and the recurrence rate was 8.7%. Of 15 patients with no response to anti-cancer treatment, 10 cases showed depressive symptoms ameliorated and the remission rate of depression was 66.7%. There were 8 recrudescence of depression after withdrawal of fluoxetine and the recurrence rate was 80.0%. [Conclusions] Fluoxetine can significantly ameliorate the depressive symptoms in patients with cancer. For patients who respond to anti-cancer therapy and have no other bodily symptoms, antidepressants should be withdrawal after remission of depressive symptoms. Long-term antidepressants taken should be recommended for patients with advanced cancer and no response to anti-cancer therapy.

关 键 词：肿瘤 氟西汀 抗抑郁药 抑郁症 

分 类 号：R730.5[医药卫生—肿瘤] R749.053[医药卫生—临床医学]