联合检测血清-腹水白蛋白梯度和腹水端粒酶对恶性腹水的诊断意义  

Clinical significance of SAAG( Serum - Ascites Albumin Gradient) in combination with ascites telomarase activity in digno-sis of malignant ascites

作　　者：叶曼玲[1] 李昌平[1] 邹义君[1] 陈果[1] 邓正华[1] 

机构地区：[1]泸州医学院附属医院消化内科,四川泸州646000

出　　处：《临床肝胆病杂志》2005年第4期220-221,共2页Journal of Clinical Hepatology

摘　　要：探讨联合检测血清-腹水白蛋白梯度(SAAG)和腹水端粒酶对恶性腹水的诊断价值。病理学诊断作为金标准,腹水标本分为试验组(18例)和对照组(26例),测SAAG(SAAG<11g/L定为阳性)及端粒酶活性,分别计算两组的SAAG均值及端粒酶OD均值、阳性例数、阳性率;如果将任意一项阳性作为诊断标准,灵敏度为88.9%,特异度为65.4%;如果将两项均为阳性作为诊断标准,灵敏度降为50%,但特异度为100%;联合检测SAAG和腹水端粒酶能显著地提高恶性腹水榆出率。To investigate the significance of SAAG combinated with the activity of ascites telomerase in diagnosis of malignant ascites. According to pathological diagnosis set as the “gold standard”, ascites were divided into experimental group 18 cases and control group 26 cases. SAAG was assayed in both experimental and control group, 〈 11 g/L was supposed to be positive. The activity of telomerase was detected too. Average SAAG, positive cases ,positive rate, average telomerase OD, positive cases, positive rate in two groups were calculated respectively. The one item positive rate and both two items positive rate in both two groups were calculated. Given one item was regarded positive, sensitivity was 88.9% and specificity 65.4%. If beth two items were regarded as positive criteria, sensitivity was 50%, but specificity amounted to 100%, specificity was higher. The combination of two assays could improve the veracity of diagnosis of malignant ascites significantly.

关 键 词：血清-腹水白蛋白梯度 端粒酶 恶性腹水 诊断 

分 类 号：R730.4[医药卫生—肿瘤]