慢性乙肝及肝硬化患者血清自身抗体结果分析  

Analysis of serum autoantibody in patients with chronic hepatitis B and patients with cirrhosis

作　　者：关伟[1] 高艳[1] 周云芳 

机构地区：[1]哈尔滨242医院,150066 [2]哈尔滨市第五医院

出　　处：《哈尔滨医药》2005年第4期10-11,共2页Harbin Medical Journal

摘　　要：目的探讨慢性乙肝及肝硬化患者血清中自身抗体的变化情况。方法收集了慢性乙肝患者120例、肝硬化43例,血清标本测定抗核抗体(AVA)和可提取性核抗原(ENA)抗体。结果慢性乙肝和肝硬化ANA的检出率分别为9.1%和18.6%,均明显高于正常对照组的1.1%(P<0.05)。两组病例间也有显著差异(P<0.05)。抗ENA抗体阳性率分别为4.1%和7.0%,阳性主要有SS-A、Sm、Scl-70、Go-1、dsDNA等多种类型。结论慢性乙肝及肝硬化患者血清自身抗体显著高于正常人。Objective： To analyze autoantibody in patients with chronic hepatitis Band patients with cirrhosis. Methods： Both antinuclear antibody （ANA） and anti-extracted nuclear antigen （ENA） antibody were detected in 120 patients with chronic hepatitis B and 43 patients with cirrhosis, respectively. Results： The frequencies of ANA were significantly higher （P〈0.05） in patients with choric hepatitis B 9.1% and cirrhosis 18.6%. The percentage of patients with cirrhosis was higher than hat of the patients with hepatitis B （P〈0.05）. The positive rate of anti-ENA antibody was 4.1% in the patients with hepatitis B and 7.0% in the patients with cirrhosis, respectively. The main types for positive results were SS-A, Sm, Scl-70, Go-1, dsDNA and etc. Conclusion： There are auto antibodies in serum of patients with chronic B and patients with cirrhosis caused by hepatitis B. he concentration is higher than normal.

关 键 词：乙型肝炎 肝硬化 自身抗体 

分 类 号：R575[医药卫生—消化系统]