Preparation of Functional Magnetic Nanoparticles and its Application in Diagnostic Analysis  

Preparation of Functional Magnetic Nanoparticles and its Application in Diagnostic Analysis

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作  者:Qiong CHENG Tu Zhi PENG Ai Li LIU 

机构地区:[1]Department of Chemistry, Xixi Campus,Zhejiang University,Hangzhou 310028 [2]College of biological and Chemical Engineering,Jiaxing Coliege, Jiaxing 314001

出  处:《Chinese Chemical Letters》2005年第8期1059-1062,共4页中国化学快报(英文版)

基  金:The work was supported by the National Natural Science Foundation of China(29975024,20275034);the Key Project of Science and Technology of Zhejiang Province(2003C21024);the Instrumental Analysis Foundation of Zhejiang Province(04062).The authors thank the Instrumental Analysis Center of Zhejiang University for special measurements.

摘  要:The magnetic nanoparticles modified with carboxyl functional group were synthesized and characterized. These nanoparticles covalently bound with hepatitis B surface antibody(HBsAb), were used to detect hepatitis B surface antigen (HBsAg) in immunovoltammetry. The detection limit was found to be 0.06 ng/mL, which is much higher than that of enzyme-linked immunosorbent assay (ELISA) used in clinical analysis.The magnetic nanoparticles modified with carboxyl functional group were synthesized and characterized. These nanoparticles covalently bound with hepatitis B surface antibody(HBsAb), were used to detect hepatitis B surface antigen (HBsAg) in immunovoltammetry. The detection limit was found to be 0.06 ng/mL, which is much higher than that of enzyme-linked immunosorbent assay (ELISA) used in clinical analysis.

关 键 词:Functional magnetic nanoparficles SYNTHESIZE characterization IMMUNOASSAY electro chemical detection 

分 类 号:O646.8[理学—物理化学]

 

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