^(131)I-抗-VEGF McAb荷瘤膀胱癌裸鼠放射免疫显像的实验研究  

The experimental study of radioimmunoimaging of ^(131)I-labeled anti-VEGF monoclonal antibody in nude mice bearing human bladder cancer

作　　者：李忠俊[1] 滕本秀[1] 程绍钧[2] 张青[3] 胡云[3] 

机构地区：[1]第三军医大学新桥医院输血科,重庆400037 [2]第三军医大学新桥医院核医学科,重庆400037 [3]第三军医大学西南医院核医学科,重庆400038

出　　处：《重庆医学》2005年第8期1123-1124,共2页Chongqing medicine

摘　　要：目的探讨131I-sc-7269放射免疫显像诊断人膀胱癌的可行性。方法Iodogen法标记抗-VEGFMcAb(sc-7269);SPECT仪行荷人浸润性膀胱癌裸鼠移植瘤模型131I-sc-7269放射免疫显像。结果131I-sc-7269荷瘤裸鼠放射免疫显像(RII)移植瘤最佳显像时间为注入标记抗体后96h。结论实验结果提示,131I-sc-7269可以放射免疫显像诊断实验性膀胱癌,为应用131I-sc-7269显像诊断人膀胱癌的临床研究提供了实验依据。Objective To explore the feasibility of ^131I-anti-VEGF McAb（sc-7269） to detect human bladder cancer. Methods sc-7269 was labeled with Na ^131I using the Iodogen method. Radioimmunoimaging of ^131I-se-7269 in nude mice bearing human bladder cancer were carried out, Results The optimum seintigraphie time of ^131I-sc-7269 to detect the T24 tumor xenograft was also about 96h after injection. Conclusion The results of present study laid a foundation for future clinical study of using ^131I-se-7269 radioimmunoimaging of bladder cancer.

关 键 词：膀胱癌 血管内皮生长因子 放射免疫显像 

分 类 号：R737.14[医药卫生—肿瘤]