结合外照射、帕米膦酸二钠和放射性核素钐-153治疗骨转移癌  

Pain relief of metastatic bone cancer by external radiation,samarium-153 and pamidronate

作　　者：张辉[1] 陈正堂[1] 张青[2] 

机构地区：[1]第三军医大学新桥医院全军肿瘤中心,重庆400037 [2]第三军医大学新桥医院核医学科,重庆400037

出　　处：《重庆医学》2005年第8期1142-1143,共2页Chongqing medicine

摘　　要：目的回顾性分析外照射、放射性核素钐-153和帕米膦酸二钠联合治疗骨转移癌疼痛的疗效及不良反应。方法应用钐-153、局部止痛性外照射、帕米膦酸二钠联合治疗56例骨转移癌疼痛患者,随访观察4个月。根据治疗后疼痛缓解和生活质量变化情况判断疗效,依据临床症状、血常规、骨髓形态学变化观察不良反应。结果治疗总有效率94.6%(53/56),其中显效率48.2%(27/56),无效率5.35%(3/56)。主要不良反应为白细胞和(或)血小板减少(49例),感冒样症状及一过性发热(22例),一过性骨痛加重(11例)。结论采用外照射、钐-153及帕米膦酸二钠联合治疗骨转移癌疼痛,是一种有效的治疗方法,可提高患者生存质量。Objective To evaluate the role of external radiation, intravenous injection of samarium-153 and pamidronate in therapy of metastatic cancer bone-pain. Methods Fifty-six patients with metastatic hones were treated with comprehensive therapy in our department during the period from June 2001 to February,2004. External radiation dose was 30-60Gy/2-6 weeks. 90mg pam idronate was intravenously given three times and samarium-153（1.0mci/kg）was once a month for three cycles after radiotherapy. Results Complete relief of hone paine was observed in 27cases（48.2%）,partial relief in 26 cases（46.4%） and no effect in 3cases （5.35%）. Total pain relief rate was 94.6% （53/56）. Side-effects related to the therapy were leakopenia and thrombocytopenia（in 49 cases） ,common cold-like symptoms（22 cases）, and transient hone pain progress （11 cases）. Conclusion Comhinative therapy of external radiation, intravenous injection samarium-153 and pamidronate is effective method to relieve metastatic cancer hone pain and increase the patients life quality.

关 键 词：外照射 钐-153 帕米膦酸二钠 骨转移癌 

分 类 号：R730.5[医药卫生—肿瘤]