丝裂霉素对于腺性膀胱炎术后膀胱灌注的疗效分析(附60例报告)  

Analysis of efficacy of bladder irrigation with mitomycin-c at high dose after surgery in cystitis glandularis

作　　者：王加强[1] 孙文涛[1] 王焱民[1] 李义[1] 王孟春[1] 

机构地区：[1]吉林省人民医院泌尿外科,吉林长春130021

出　　处：《吉林医学》2005年第8期824-825,共2页Jilin Medical Journal

摘　　要：目的:提高腺性膀胱炎综合治疗效果。方法:腺性膀胱炎患者60例,膀胱镜检表现为滤泡状或绒毛状40例、乳头瘤样16例、慢性炎症4例。术前活检病理报告腺性膀胱炎。行经尿道电切加气化术,术后丝裂霉素20mg膀胱灌注,规律治疗2年,方案为每周1次共8次,其后每月1次共2年。定期做膀胱镜检查,并行组织学观察。结果:随访6￣70个月,平均25个月。55例痊愈,膀胱黏膜逐渐恢复为移行上皮覆盖;4例复发;1例腺癌变。结论:经尿道电切加气化,术后丝裂霉素灌注治疗腺性膀胱炎,有助于膀胱上皮的组织学转归。Objective To evaluate the comprehensive treatment results of cystitis giandularis. Method A total of 60 cases with cystitis glandularis underwent cystoscopy.The results showed follicular or villous changes in 40 cases,papillomatous in 16,chronic inflammation in 4. Transurethral electric resection or partial cystectomy were performed.After surgery all the cases received mitomycinc bladder irrigation at high dose （20mg once） regularly for 2 years. The follow-up cystoscopy was periodically performed and the biopsy samples were pathologically examined with all the cases. Results The mean follow-up time was 25 months （from 6 to 70 months）.Of the 60 cases,55 fully recovered with transitional cell surface covering the bladder musoca gradually,4 had relapse and 1 developed canceration（adenocarcinoma）. Conclusion Transurethral resection of bladder tumors or galvanocautery is the essential therapy for cystitis glandularis.After surgery the bladder irrigation with mitomycin-c at high dose can be helpful for urothelium recover in histology.

关 键 词：腺性膀胱炎 丝裂霉素 膀胱灌注 

分 类 号：R737.14[医药卫生—肿瘤] R694[医药卫生—临床医学]