胃癌患者手术前后血浆胆固醇水平研究  

The study of perioperative serum cholesterol in patients with gastric cancer

作　　者：王春祥[1] 王培林[2] 智绪亭[3] 

机构地区：[1]山东省济南市第三人民医院普外科,山东济南250101 [2]山东大学第二医院普外科,山东济南250033 [3]山东大学齐鲁医院普外科,山东济南250012

出　　处：《中国现代普通外科进展》2005年第4期240-242,共3页Chinese Journal of Current Advances in General Surgery

基　　金：山东省卫生厅科研基金资助项目(1999CAAB2)

摘　　要：目的:了解胃癌及胃溃疡病人手术前后血浆胆固醇水平及其与胃癌组织分化程度的相关性。方法:术前及术后10d测定150例胃癌和30例胃溃疡病人以及不同胃癌组织病理类型血浆胆固醇含量,进行统计学分析。结果:胃癌术前血浆胆固醇水平显著降低(P0.01);胃癌术后较术前血浆胆固醇升高(P0.05),与胃溃疡术后差异无统计学意义。胃癌B组(组织分化差)术前血浆胆固醇较A组(组织分化好)降低(P0.05),A、B组手术后血浆胆固醇均升高,各自与术前相比,A组差异无统计学意义(P0.05),B组差异有统计学意义(P0.01)。结论:胃癌特别是进展期胃癌患者,术前血浆胆固醇水平降低,术后升高;降低、升高的程度与组织分化程度相关,癌组织分化越差,术前后血浆胆固醇降低、术后升高的程度越明显。Objective：To understand the levels of serum cholesterol in patients with gastric cancer and gastric ulcer before and after operation,and to study the relationship between the level of serum cholesterol and the tissues differential degree of gastric cancer.Methods：To survey the content of serum cholesterol in patients with gastric cancer and patients with gastric ulcer confirmed clinically before and after operation,looking through the medical records of the patients and taking notes about the tissues differentiated degree of the gastric cancer,then making the statistical analysisi.Results：Comparing with the normal control group,the level of serum cholesterol in gastric cancer decreased obviously before operation,there was obvious statistical difference（P〈0.01）,and increased after operation,comparing with themselves before operation was statistical difference（P〈0.05）,and no statistical difference comparing with the normal control group after operation.There was statistical difference between the higher （group A） and the lower（group B）differentiated degree of gastric cancer tissues（P〈0.05） before operation and no statistical difference after operation.After operation the levels of serum cholesterol in group A and group B were all increased.Comparing with the level of serum cholesterol before operation each other,there was obvious statistical difference（P〈0.01） in group B and no statistical difference（P〉0.05）in group A.Conclusion：The level of serum cholesterol in patients with gastric cancer decreased before operation and increased after operation,especially in progressive gastric cancer.There was correlation between the level of serum cholesterol and the tissues differentiated degree of gastric cancer.The lower the tissues differentiated degree of gastric cancer was ,the lower before operation and the higher after operation the level of serum cholesterol were.

关 键 词：胃肿瘤 胃溃疡 胆固醇 

分 类 号：R735.2[医药卫生—肿瘤]