结肠黑变病致病因素分析及与结肠肿瘤的关系探讨  

Clinical analysis on melanosis coli: risk factor, relationship with colorectal neoplasia

作　　者：王芬[1] 沈守荣[1] 王晓艳[1] 肖定华[1] 郭勤[1] 

机构地区：[1]中南大学湘雅三医院消化内科,湖南长沙410013

出　　处：《中国现代医学杂志》2005年第15期2332-2334,共3页China Journal of Modern Medicine

基　　金：湖南省自然科学基金(No:03JJY2004)

摘　　要：目的探讨结肠黑变病(melanosiscoli,MC)的病因、发病特点,以及MC与结肠肿瘤、结肠腺瘤性息肉的关系。方法对37名MC患者的临床资料(是否合并便秘,是否服用泻药以及服药方式、时间)、镜下表现及病理检查结果进行回顾性分析;同时统计同期非MC患者的腺瘤性息肉检出率及癌变率。结果MC患者均有便秘史,其中31名患者有明确服用泻药史;37人中有3例发生腺瘤性息肉,其中2例癌变。结论便秘及服用泻药是导致MC发生的重要因素;MC与结肠癌、结肠腺瘤性息肉的发生无统计学意义上的相关性。[Objective] To evaluate the risk factor for Melanosis Coli.To investigate the relationship between Melanosis Coil and colorectal neoplasia. [Methods] 37 patients with melanosis coil diagnosed by endoscopy and histopathological examination were retrospectived analyzed on their history of constipation, laxatives use. [Results] All the cases had constipation and 31 cases had histroy of laxatives use.3 cases had colorectal adenomas with 2 of which had carcinoma. [Conclusion] Melanosis coli is mainly related with constipation and abuse of laxatives and but were not significant risk factors for the development of colorectal adenomas or colorectal carcinomas.

关 键 词：结肠黑变病 便秘 泻药 结肠癌 结肠腺瘤性息肉 

分 类 号：R574.62[医药卫生—消化系统]