人类喉癌YB-1蛋白表达的临床意义  

Clinical implication of YB-1 protein experession in laryngeal carcinomas

作　　者：李锦绣[1] 顾春东[1] 河野宫俊 

机构地区：[1]大连医科大学第一临床学院,辽宁大连116011 [2]日本产业医科大学分子生物学教研室

出　　处：《大连医科大学学报》2005年第4期253-255,259,共4页Journal of Dalian Medical University

基　　金：辽宁省博士科研启动基金(20031065)

摘　　要：[目的]探讨人类喉癌中YB-1蛋白表达的临床意义。[方法]应用免疫组织化学方法检测了89例人类喉癌标本中YB-1蛋白的表达情况。[结果]89例人类喉癌组织中YB-1蛋白阳性率为56.2%。病理分期Ⅲ—Ⅳ期喉癌YB-1蛋白表达阳性率(76.0%)明显高于Ⅰ—Ⅱ期(48.4%)(P=0.0185)。YB-1蛋白表达与喉癌淋巴结转移密切相关(P=0.0022)。Kaplan-Meier生存曲线分析表明YB-1蛋白阳性者的术后生存率(65.5%)明显低于YB-1蛋白阴性者(86.7%)(P=0.0045)。[结论]人类喉癌标本中YB-1蛋白的检测有利于对喉癌患者的诊断、局部淋巴结转移和预后情况作出客观判断。[ Objective] To study the clinical significance of detection YB - 1 protein expression in laryngeal carcinoma. [ Methods] YB- 1 protein expression were detected in 99 laryngeal carcinoma samples with immunohistochemistry. [ Results] The positive rate of YB- 1 protein expression in laryngeal carcinoma was 56.2%. The frequency of YB - 1 protein expression in stage Ⅲ - IV was significantly higher than that in stage Ⅰ- Ⅱ（P = 0.018 5）.YB- 1 protein expression was associated with lymph node metastasis （ P = 0. 0022）. The patients with YB - 1 positive expression had significantly shorter survival periods （65.5 % ） than those with YB- 1 protein negative expression （86.7%） （P = 0.004 5, log-rank test）. [Conclusion] It suggested that the detection of human YB - 1 protein expression in laryngeal carcinoma samples may be helpful in judging the diagnosis, lymph nodes metestasis and prognosis.

关 键 词：YB-1蛋白 喉癌 预后 

分 类 号：R739.65[医药卫生—肿瘤]