骨髓形态学在单核细胞白血病诊断中的作用  

Role of cytochemical staining in diagnosis of monocytic leukemia

作　　者：尉岩[1] 闫晨华[1] 史惠琳[1] 刘艳荣[1] 邱镜莹[1] 江滨[1] 王德炳[1] 

机构地区：[1]北京大学人民医院血液病研究所,100044

出　　处：《中华放射医学与防护杂志》2005年第4期354-356,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的探讨骨髓形态学(包括细胞化学染色)在急性单核细胞白血病(AMLM5)和急性粒单核细胞白血病(AMLM4)形态学、免疫学及细胞遗传学(MIC)分型中的作用。方法对47例初治AML的骨髓穿刺标本进行形态学、免疫表型和染色体检查,并对检查结果进行分析。结果47例形态学诊断为AMLM4和AMLM5的患者最终经MIC分型诊断为AMLM525例;AMLM419例(其中AMLM4Eo5例);t(8;21)AML2例;T细胞性急性淋巴细胞白血病(TALL)1例。结论在AMLM4及AMLM5的MIC分型中,骨髓形态学仍具有重要的的诊断价值,免疫分型和染色体检查与形态学相互依存,有助于进一步提高诊断的准确率。Objective To explore the role of cytochemical staining in MIC（morphology, immunology and cytogenetics） typing of acute monocytic leukemia （ AML-M5 ） and acute myelomonocytic leukemia （ AML-M4 ）. Methods We analyzed the characteristics of morphology, immunology and cytogenetics in 47 cases of diagnosed AML. Results Eventually,they were diagnosed with MIC.There were 25 cases with AML-MS,19 cases with AML-M4（consisted of 5 cases diagnosed AML-M4Eo）,2 cases with acute myeloid leukemia with t（8：21 ） and 1 case with T-ALL. Conclusions During MIC typing of AML-M4 and AML-M5, the diagnostic value of morphology remains important, for immunophenotype, cytogenetics and morphology are interdependent. Immunophenotype and cytogenetics are necessary for improvement of the accuracy rate of diagnosis.

关 键 词：骨髓形态学 单核细胞 白血病 染色体 免疫分型 

分 类 号：R733.7[医药卫生—肿瘤]