肿瘤标记物蛋白芯片对肺癌的诊断价值  

Diagnostic value of protein-chip by detecting tumor markers for lung cancer

作　　者：林海龙[1] 崔社怀[1] 曹国强[1] 梁先万[1] 康军[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所呼吸内科,重庆400042

出　　处：《第三军医大学学报》2005年第15期1591-1592,共2页Journal of Third Military Medical University

摘　　要：目的研究肿瘤标记物蛋白芯片对肺癌的诊断价值。方法将96例已经确诊的病例分为肺癌组和非肺癌组,采用蛋白芯片测量技术检测肺癌组和非肺癌组其血清肿瘤标记物。结果①肺癌组和非肺癌组12项标记物中糖链抗原19-9(CA19-9),神经元特异性烯醇化酶(NSE),癌胚抗原(CEA),糖链抗原242(CA242)癌抗原125(CA125)、铁蛋白6项测定值差异有显著性(P<0.01)。②肺癌组和非肺癌组12项标记物阳性检测中6项测定阳性率差异有显著性(P<0.01)。其中肺癌组CEA,CA242和CA 125呈现高阳性检测率。结论肿瘤标记物蛋白芯片对肺癌的诊断有重要的价值。Objective To investigate the role of protein-chip by detecting the changes of tumor markers for diagnosis of lung cancer. Methods A total of 96 patients with definite diagnosis were divided into 2 groups： lung cancer group （n = 48） and control group （ n = 48）. Using the protein-chip technique, the twelve tumor markers were detected into the two groups. Results The serum content of in measuring value of CA19-9, NSE, CEA, CA242, Ferritin, CA125 in the twelve tumor markers showed statistical significance between two groups （P 〈0.01 ） and CEA, CA242 and CA125 had high positive rates in lung cancer group. Conclusion Detecting tumor markers by protein-chip has an important value in diagnosis of lung cancer.

关 键 词：肺癌 肿瘤标记物 蛋白芯片 

分 类 号：R394-33[医药卫生—医学遗传学] R734.2[医药卫生—基础医学]