紫菜多糖的免疫功能增强作用  

Immunologic enhancement of Porphyra polysaccharide

作　　者：闫建忠[1] 吕昌龙[1] 李胜军[1] 刘英杰[1] 李季[1] 

机构地区：[1]中国医科大学基础医学院免疫学教研室,辽宁沈阳110001

出　　处：《中国海洋药物》2005年第4期36-38,共3页Chinese Journal of Marine Drugs

摘　　要：目的探讨紫菜多糖对免疫功能低下小鼠的保护作用。方法小鼠腹腔注射不同剂量(0.025,0.050和0.150g.kg-1)的紫菜多糖,每日1次,连续7d,并在给予紫菜多糖的第1d,2d同时注射环磷酰胺造成免疫功能低下模型,第8d检测小鼠的NK细胞细胞毒活性,以及脾细胞分泌IFN-γ和NO的水平。结果0.150g.kg-1紫菜多糖组小鼠的NK细胞毒活性、脾细胞分泌IFN-γ及NO的水平均高于模型组。结论紫菜多糖具有一定的免疫功能增强作用。Objective To investigate the immunologic enhancement of Porphyra polysaccharide. Methods Porphyra polysaccharide in different dosages （0. 025,0. 050,0. 150g · kg^-1）were injected intraperitoneally into the immunosuppressive mice induced by cyclophosphamide for 7d. On day 8,the cytotoxic activity of NK cells,the levels of interferon-γ（IFN-γ）and nitric oxide （NO）in the cultured supernatants of spleen cells were determided. Results The cytotoxic activity of NK cell, the levels of IFN-γ, and NO produced by cultured spleen cells from the group of mice treated with 0. 150g · kg^-1 of Porphyra polysaccharide were higher than those from model group. Conclusion Porphyra polysaccharide could enhance immunological functions to a certain degree in immunosuppressive mice.

关 键 词：紫菜多糖 环磷酰胺 免疫调节 免疫功能低下模型 增强作用 NK细胞毒活性 IFN-Γ 腹腔注射 细胞分泌 保护作用 

分 类 号：R285.5[医药卫生—中药学] R151.3[医药卫生—中医学]