诱导肿瘤细胞分化凋亡药物在肝胆肿瘤区域性联合化疗中的应用  

Preliminary clinical study on differentiation and apoptosis of tumor cells induced by regional combination chemotherapy for hepatobiliary neoplasm

作　　者：于志坚[1] 蔡炜[1] 袁洪新[1] 袁烨[1] 李小彦[1] 

机构地区：[1]南通大学附属医院肿瘤中心,南通226001

出　　处：《南通大学学报（医学版）》2005年第4期261-263,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:为提高诱导肿瘤细胞分化与凋亡药物临床治疗效果。方法:采用三氧化二砷、羟基喜树碱与顺氯氨铂、5-氟尿嘧啶等组成联合化疗方案,经肿瘤供血脉管行区域性灌注栓塞,结合全身应用,治疗经常规介入化疗病灶缩小后获手术切除但又复发肝癌、肝癌姑息性切除术后常规化疗药物局部介入治疗无效者,及晚期广泛转移的胆管癌。结果:3种临床类型肝胆系统晚期肿瘤,均取得缓解症状、稳定病情或AFP下降等较好疗效。结论:将三氧化二砷、羟基喜树碱组成联合化疗方案,经肿瘤供血脉管输注,可起到缩小实验室与临床研究的客观差距,提高疗效的作用。Objective：To improve the clinical efficacy of chemotherapy which can induce differentiation and apoptosis of the tumor cells. Methods： The combination chemotherapy regimen consists of effective drugs （As2O3 and HCPT） and conventional drugs（DDP, 5-Fu ,etc. ）. By means of infusion and embolization via the feeding vessel of tumor integrating with adjuvant intravenous chemotherapy, we can treat many types of hepatobiliary neoplasms such as postoperative recurrence of liver cancer, refractory liver cancer afer palliative hepatectomy and conventional intervention treatment subsequent to the former,and advanced cholangiocarcinoma with far-ranging metastasis. Results：The patients with three types of advanced hepatobiliary neoplasms all obtained symptom relief, disease stabilization and AFP value decline. Conclusion： According to the principle of the strong-to-strong combination, As2O3 and HCPT have been combined to form an effective regimen, infused via the feeding vessel of tumor, which can improve the efficacy and reduce the gap between laboratory and clinical research.

关 键 词：原发性肝细胞癌 三氧化二砷 羟基喜树碱 诱导分化凋亡 区域性联合化疗 

分 类 号：R735.7[医药卫生—肿瘤]