后程加速超分割放射治疗食管癌的临床研究  

Result of late-course accelerated hyper fractionated radiotherapy for esophageal carcinoma

作　　者：陈意红[1] 

机构地区：[1]皖南医学院弋矶山医院肿瘤放疗中心,芜湖241001

出　　处：《安徽医学》2005年第5期369-371,共3页Anhui Medical Journal

摘　　要：目的比较后程加速超分割(LCAF)和常规分割放射治疗食管癌的疗效和毒性。方法64例食管癌患者随机分成两组,CF组(32例)1次/d,2Gy/次,5次/周,总剂量60～68Gy,30～34次,6～7周完成;LCAF组(32例)前36Gy照射常规分割完成,36Gy后缩野改加速超分割,1.5Gy/次,2次/d,照射剂量24～30Gy,总剂量60～66Gy,34～38次,5.2～5.6周完成。结果所有病例均完成疗程,两个组急性反应差异无显著意义(P>0.05)。1、3、5年生存率CF组分别为46.9%,21.9%,12.5%,LCAF组分别为53.1%,28.1%,15.6%,两个组差异无显著意义(P>0.05);1、3、5年局部控制率CF组分别为40.6%,25%,21.9%,LCAF组分别为62.5%,53.1%,43.8%,LCAF组优于CF组。结论食管癌后程加速分割放射治疗的局控率优于常规放射治疗组,生存率之间差异无显著意义,毒性反应无明显增加。Objective To compare the result and side-effect late-course accelerated hyper fraction （LCAF） regimen and conventional fractionation （CF） regimen in the radiotherapy for esophageal carcinoma. Methods Sixty-four patients with esophageal carcinoma were randomized into two groups. The CF group received routine radiotherapy 2 Gy per day ,5 times a week to a total dose of 60～68 Gy in 6～7 weeks. The LCAF group received conventional fractions in the first part of the treatment to a dose 36Gy/18 f/3.6 w, followed by accelerated fractionated irradiation using reduced fields, twice daily at 1.5 Gy per fraction with a minimum interval of 6 hours between fractions. The dose by the accelerated technique was 24～30 Gy. So the total dose of 60～66 Gy/34～38 f/5.2～5.6 w. Results There were no significant difference in acute response between groups （P〉0.05）. The 1,3,5-year local tumor control rates of LCAF group were significantly improved when compared to CF group, being 62.5% ,53.1% ,43.8% vs 40.6% ,25% ,21.9% respectively （P〈0.05）. The 1,3,5-year surival rates were 53.1% ,28.1%, 15.6% in LCAF group and 46.9%,21.9% ,12.5% in CF group （P〉0.05）. Conclusion local control rate of late-course accelerated hyper fractionated of esophageal carcinoma is better than the conventional radiotherapy, however there is no significant difference in survival rate between two groups. It is well to lerated.

关 键 词：食管肿瘤 放射疗法 后程加速分割放射治疗 后程加速超分割放射治疗 食管癌 临床研究 常规分割放射治疗 加速分割放射治疗 5年生存率 LCAF 

分 类 号：R735.1[医药卫生—肿瘤] R734.2[医药卫生—临床医学]