肝纤维化指标在甲亢、甲低患者中的对比分析  

Changes of Hepatofibrosis Markers in Hyperthyroidism and Hypothyroidism

作　　者：王玲珑[1] 张春燕[1] 屠丽萍[1] 俞月芳[1] 朱伟杰[1] 

机构地区：[1]浙江省嘉兴市第一医院核医学科,314001

出　　处：《放射免疫学杂志》2005年第4期275-277,共3页Journal of Radioimmanology

摘　　要：目的:探讨甲状腺功能亢进(甲亢)、甲状腺功能减低(甲低)与肝纤维化指标的关系及其可能的机制。方法:用放射免疫分析(RIA)检测57例甲亢患者、43例甲低患者、39例甲亢治疗后甲状腺激素正常者和50例健康成人的血清Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、层粘连蛋白(LN)、TT3、TT4、FT3、FT4、sTSH、TGA、TMA含量。结果:甲亢患者组血清中Ⅳ-C、PCⅢ含量比正常对照组及甲低患者组显著性增高(P<0.01);治疗后甲状腺激素下降,Ⅳ-C、PCⅢ含量也随之下降(与治疗前比较P<0.01);HA、LN在四组中无显著性差异(P>0.05),在甲亢治疗前后无显著性差异(P>0.05)。各项肝纤维化指标与TGA、TMA的阳性率无关。结论:甲亢患者血清中甲状腺激素含量增高时,Ⅳ-C、PCⅢ含量也增高,在用Ⅳ-C、PCⅢ判断肝纤维化时应注意有无甲状腺疾病特别是甲亢。未发现HA、LN含量与甲状腺激素水平的关系。Objective To study the changes of hepatofibrosis markers in hyperthyroidism and hypothyroidism. Methods The indicators of thyroid function （ TT3 , TT4, FT3 , FT4, sTSH, TG - Ab, TM - Ab） and hepatofibrosis markers （ Ⅳ - C, PC Ⅲ, HA, LN） were assayed with RIA in 57 patients with hyperthyroidism, 43 patients with hypothyroidism, 39 euthyroid patients after hyperthyroidism treated and 50 controls. Results The serum Ⅳ- C and PCⅢ levels in hyperthyroid patients were significantly higher than those in controls and hypothyroid patients （ P 〈 0.01 ）. In the euthyroid subjects after successful treatment, the Ⅳ - C and PCⅢ levels dropped markedy （vs before treatment, P 〈0.01 ）. However, there were no significant differences among the serum HA, LN levels in all the subjects tested. Conclusion Serum levels of Ⅳ- C and PCⅢ increased markedly during hyperthyroidism. When Ⅳ - C and PCⅢ levels were taken for judgement of degree of hepatofibrosis, hyperthyroidism must be ruled out first. The HA and LN levels were not related to the status of thyroid function.

关 键 词：肝纤维化 甲状腺功能亢进 甲状腺功能减低 透明质酸 Ⅲ型前胶原 实验室检查 

分 类 号：R575.2[医药卫生—消化系统] R581[医药卫生—内科学]