直肠癌患者手术前后血可溶性P选择素和TNF水平检测的临床意义  

Clinical Significance of Determination of Changes of Blood P-selectin and TNF Levels After Operation in Patients with Rectal Cancer

作　　者：陈慧玉[1] 

机构地区：[1]江苏省连云港市第一人民医院外科,222002

出　　处：《放射免疫学杂志》2005年第4期282-283,共2页Journal of Radioimmanology

摘　　要：目的:探讨直肠癌患者手术治疗前后血可溶性P选择素和TNF水平的变化及临床意义。方法:分别应用放免法和ELISA法测定了34例直肠癌患者手术治疗前血可溶性P选择素和TNF含量,并与30名正常健康人作比较。结果:直肠癌患者手术治疗前后血可溶性P选择素和TNF水平非常显著地高于正常人组(P<0.01),手术治疗后一年,复发组又非常明显地高于未复发组(P<0.01)。结论:测定直肠癌患者手术治疗前后血可溶性P选择素和TNF水平检测的变化与直肠癌患者的病情和预后密切相关,均具有重要的临床价值。Objective To study the clinical significance of changes of blood P - selectin and TNF levels after operation in patients with rectal cancer. Methods Serum TNF （with RIA） and plasma P -selectin （with ELISA） levels were determined in 34 patients with rectal cancer both before and after operation as well as in 35 controls, Results Before operation, blood P - selectin and TNF levels were significantly the higher in the patients than those in controls （P 〈0, 01 ）, Twenty - two of the 30 patients underwent operation showed no sign of recurrence at 1 year and their blood P - selectin and TNF levels dropped to within normal range. Hower in the 8 patients with recurrence, blood levels of P - selectin and TNF remained abnormally high （ vs those without recurrence, P 〈 0. 01 ）. Conclusion Blood P - selectin and TNF levels were closely related to the disease process of rectal cancer and were of prognostic values.

关 键 词：直肠癌 手术治疗 可溶性P选择素 血液检查 肿瘤坏死因子 

分 类 号：R735.37[医药卫生—肿瘤] R730.56[医药卫生—临床医学]