子宫癌和子宫肌瘤患者血清PRL、T和E_2含量的变化  

Changes of Serum Levels of Prolactin (PRL), Testosterone (T) and Estriol (E_2) in Patients with Uterine Myoma and Endometriocarcinoma

作　　者：沈卫[1] 蔡金来[1] 周雅琴[1] 高峥[1] 潘芳芳[1] 徐美华[1] 

机构地区：[1]上海市杨浦区中心医院核医学科,200092

出　　处：《放射免疫学杂志》2005年第4期319-320,共2页Journal of Radioimmanology

摘　　要：目的:探讨人血清催乳素(PRL)、睾酮(T)和雌二醇(E2)与子宫肌瘤、子宫癌的关系。方法:采用化学发光免疫法(CLIA)分别检测了子宫肌瘤患者(30例)、子宫癌患者(28例)的血清PRL、T和E2三类激素并与健康人组(38人)比较。结果:1.子宫肌瘤和子宫癌的PRL和T含量均明显高于正常组(P<0.01)。2.子宫肌瘤与子宫癌组的E2水平与正常人无明显差异(P>0.01)。3.从正常人组经子宫肌瘤患者到子宫癌组其血PRL水平呈持续增高趋势。结论:PRL和T含量的变化与子宫肌瘤及子宫癌疾患有密切关系。Objective To study the relationship between the serum levels of PRL, T, E2 and development of uterine myoma/endometriocarcinoma. Methods Serum PRL, T and E2 levels were determined with CLIA in 30 patients with uterine myoma, 28 patients with endometriocarcinoma and 38 controls. Results ①Serum levels of PRL and T in beth the patient groups were significantly higher than those in controls （P 〈0.01 ）, ②The E2 levels in beth patient groups were not significantly different from those in controls （P 〉0.01 ）, ③The serum PRL levels were lowest in the controls and highest in patients with endometriocarcinoma while levels in patients with uterine myoma were intermediate. Conclusion With the development of uterine myoma/endometriocarcinoma the serum PRL and T levels increased significantly.

关 键 词：子宫癌 子宫肌瘤 血清 催乳素 睾酮 雌二醇 含量检测 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]