失代偿期肝硬化患者血锌、氧自由基水平及抗氧化酶活性观察  

Clinical Observation on Levels of Serum Zinc and Oxygen Free Radical and Activity of Antioxidase in Decompensated Hepatic Cirrhosis

作　　者：马永福[1] 王家翠[1] 李桂萍[1] 崔蓉[1] 寸丽玲[1] 黄琛[1] 

机构地区：[1]昆明医学院第一附属医院消化内科,昆明中心实验室

出　　处：《昆明医学院学报》1995年第4期48-50,共3页Journal of Kunming Medical College

摘　　要：研究了肝硬化（ＨＣ）患者血清锌、血清脂质过氧化物一丙二醛（ＭＤＡ）及超氧化物歧化酶（ＳＯＤ）的含量及其意义．结果表明，肝硬化患者血清锌明显减低（Ｐ＜０．０００１）；ＭＤＡ明显增加（Ｐ＜０．００１），ＳＯＤ明显减少（Ｐ＜０．０００１）．血清锌含量与血清ＭＤＡ含量（ｒ＝０．１６７，Ｐ＞０．０５）及ＳＯＤ含量（ｒ＝０．２１２，ｐ＞０．００５）皆无相关．结果提示，ＨＣ患者补给锌及ＳＯＤ是必需而有益的．The serum levels and significance of serum Zinc．Lipid peroxide（LPO ）-Malondialdeyde（MAD） and activity of superoxide dismutase（SOD） were studied in patients with decompensated hepatic cirrhosis（DHC）．The results showed that the levels of serum Zinc and SOD were significantly lower（P＜0．000 1 and P＜0．000 1）and the level of serum MDA was significantly higher（P＜0．001） in the DHC group than in the normal contral group．No correlation was shown between serum levels of Zinc and MDA or activity of SOD of patient of the DHC（r=0．167， P ＞0．05 and r=0．212，P＞0．05）． Our conclusion is that suppling Zinc and SOD is necessary and useful in the treatment of patients with DHC．

关 键 词：肝硬变 锌 氧自由基 抗氧化酶 

分 类 号：R575.202[医药卫生—消化系统]